Ischaemia-reperfusion injury of rat ovary and the effects of vitamin C, mannitol and verapamil

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dc.contributor.authorSagsöz, N.
dc.contributor.authorKısa, Ü.
dc.contributor.authorApan, A.
dc.date.accessioned2020-06-25T17:34:57Z
dc.date.available2020-06-25T17:34:57Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractBACKGROUND: In this prospective controlled study, the aim was to examine the effects of vitamin C, mannitol and verapamil on adnexial ischaemia-reperfusion injury in the rat ovary. METHODS: Thirty-six female Wistar rats were used. In the controls (group 1), only laparotomy was performed. In group 2, ovarian ischaemia was produced and the bilateral ovaries were surgically removed 4 h later. In group 3, an ischaemic period of 4 h was followed by reperfusion for 1 h; the bilateral ovaries were then removed. In groups 4, 5 and 6, after 4 h of ischaemia, either vitamin C, mannitol or verapamil respectively was infused before reperfusion; after 1 h of reperfusion the ovaries were removed. Thiobarbituric acid reactive substance (TBARS) levels were measured in all ovary tissues. RESULTS: TBARS levels of the reperfusion group were significantly higher than those of groups treated with vitamin C or mannitol (P = 0.013 and P = 0.045 respectively), but not of the verapamil group. CONCLUSIONS: Vitamin C and mannitol were found to be effective in reducing ischaemia-reperfusion injury of the ovary during its early stages, but verapamil was ineffective.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1093/humrep/17.11.2972
dc.identifier.endpage2976en_US
dc.identifier.issn0268-1161
dc.identifier.issue11en_US
dc.identifier.pmid12407059
dc.identifier.scopus2-s2.0-0036852092
dc.identifier.scopusqualityQ1
dc.identifier.startpage2972en_US
dc.identifier.urihttps://doi.org/10.1093/humrep/17.11.2972
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2966
dc.identifier.volume17en_US
dc.identifier.wosWOS:000179305200032
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofHuman Reproduction
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmannitolen_US
dc.subjectovaryen_US
dc.subjectreperfusionen_US
dc.subjectverapamilen_US
dc.subjectvitamin Cen_US
dc.titleIschaemia-reperfusion injury of rat ovary and the effects of vitamin C, mannitol and verapamilen_US
dc.typeArticle

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