Antibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries: a randomised controlled trial

dc.contributor.authorAlmaz, Merve Erkmen
dc.contributor.authorOba, Aylin Akbay
dc.date.accessioned2021-01-14T18:10:41Z
dc.date.available2021-01-14T18:10:41Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractObjectives The aim of this study was to compare the antibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries (S-ECC). Materials and methods The study was conducted in 92 children with S-ECC. Patients who completed dental treatment under general anaesthesia were included in the study. Patients were divided randomly into four groups: 5% sodium fluoride (SF) control group (n = 23), 5% SF with tricalcium phosphate (TCP) (n = 23), 5% SF with xylitol-coated calcium and phosphate (CXP) (n = 23) and 5% SF with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) (n = 23). Saliva mutans streptococci (MS) and lactobacilli (LB) levels were evaluated by taking saliva samples at baseline (T-0), 1 month (T-1) and 3 months (T-2) after treatment. Results All groups showed a significant decrease in MS and LB levels at T-1 (P < 0.05) except the CXP group. Only the TCP group exhibited significantly decrease MS and LB levels indicating less than 10(5) CFU at both T-1 and T-2 compared with the other groups (P < 0.05). Conclusion Fluoride varnish with TCP provided significantly more reduction in MS and LB levels than other fluoride varnishes. Clinical Trials registration number NCT03625310en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination UnitKirikkale University [2015/032]en_US
dc.description.sponsorshipThis study was funded by the Kirikkale University Scientific Research Projects Coordination Unit (project number 2015/032).en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1007/s00784-020-03300-w
dc.identifier.endpage2136en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue6en_US
dc.identifier.pmid32356211
dc.identifier.scopus2-s2.0-85084233231
dc.identifier.scopusqualityQ1
dc.identifier.startpage2129en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-020-03300-w
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12728
dc.identifier.volume24en_US
dc.identifier.wosWOS:000529855300002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofCLINICAL ORAL INVESTIGATIONS
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBacteriaen_US
dc.subjectChildrenen_US
dc.subjectDental cariesen_US
dc.subjectFluoride varnishesen_US
dc.titleAntibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries: a randomised controlled trialen_US
dc.typeArticle

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