The concomitant use of USP28 and p53 to predict the progression of urothelial carcinoma of the bladder

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dc.contributor.authorDevrim, Tuba
dc.contributor.authorAtac, Fatih
dc.contributor.authorDevrim, Alparslan Kadir
dc.contributor.authorBalci, Mahi
dc.date.accessioned2021-01-14T18:11:07Z
dc.date.available2021-01-14T18:11:07Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractThe Ubiquitin Specific Peptidase 28 (USP28) is a deubiquitinase involved in the DNA damage pathway. Recently, USP28 protein is reported to play roles in the mechanism of p53 action and could be a possible prognostic marker for bladder cancer (BCa). This study aims to explore the relation of USP28 with tumor growth and invasion, and also to investigate the interplay between USP28 and p53 in BCa. Expression levels of USP28 and p53 in human BCa (invasive and non-invasive, n = 43) and control tissues (n = 8) were evaluated by immunohistochemistry and quantitative real-time polymerase chain reaction (qPCR) profiling. The relationship between protein and gene expression levels, clinicopathologic features and prognosis were evaluated. Significant positive correlations were found between BCa tumor progression and the USP28 expression, and also between the USP28 and p53 scores (p all < 0.05). Immunohistochemistry staining percentages were strongly correlated between USP28 and p53, and also positive correlations between tumor progression and p53 expressions were determined (p all < 0.001). Interestingly, USP28 and p53 were highly expressed and correlated in BCa. Consequently, the immunohistochemistry and qPCR results reported in our study suggested the idea that USP28 in coordination with p53 could serve as a marker in BCa progression.en_US
dc.description.sponsorshipScientific Research Projects Office of Kirikkale University [2018/023]en_US
dc.description.sponsorshipThis research (project no. 2018/023) was supported by Scientific Research Projects Office of Kirikkale University. We thank our colleagues Dr. Mahmut SOZMEN and Dr. Z. Sema OZKAN, who provided insight and expertise that greatly assisted the research.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1016/j.prp.2019.152774
dc.identifier.issn0344-0338
dc.identifier.issue1en_US
dc.identifier.pmid31822365
dc.identifier.scopus2-s2.0-85076237546
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.prp.2019.152774
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12884
dc.identifier.volume216en_US
dc.identifier.wosWOS:000523597200011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherELSEVIER GMBHen_US
dc.relation.ispartofPATHOLOGY RESEARCH AND PRACTICE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladder canceren_US
dc.subjectUSP28en_US
dc.subjectp53en_US
dc.subjectInvasionen_US
dc.subjectProgressionen_US
dc.subjectPrognosisen_US
dc.titleThe concomitant use of USP28 and p53 to predict the progression of urothelial carcinoma of the bladderen_US
dc.typeArticle

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