The Effects of Colchicine on the Histopathological Findings of Celiac Disease During Familial Mediterranean Fever Treatment

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dc.contributor.authorAlpcan, Aysegul
dc.contributor.authorGulerman, Hacer Fulya
dc.contributor.authorKandur, Yasar
dc.contributor.authorTursun, Serkan
dc.contributor.authorZengin, Mehmet
dc.date.accessioned2025-01-21T16:45:24Z
dc.date.available2025-01-21T16:45:24Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractFamilial mediterranean fever (FMF) and Celiac Disease (CD) are both autoinflammatory and autoimmune diseases with common clinical features affecting the gastrointestinal system. Familial mediterranean fever may coexist with CD. Inflammatory cells and cytokines are up-regulated within the intestinal mucosa of patients with CD. In this perspective, lymphocyte infiltration to the lamina propria of the small intestinal mucosa is a critical pathological sign. In the present study, we aimed to find out whether the treatment of an FMF patient with colchicine affects the pathological signs of concomitant developed CD on the same patient. We retrospectively reviewed the medical records of 147 patients with FMF who were followed up in our center between 2015 and 2020. Of the 147 patients with FMF, 3 patients also had CD. In this report, we presented these 3 cases. The findings obtained in this study suggest that pathological findings may be misinterpreted in autoimmune diseases, such as CD, when patients administer anti-inflammatory treatments, such as colchicine.
dc.identifier.doi10.1177/10935266221077572
dc.identifier.endpage473
dc.identifier.issn1093-5266
dc.identifier.issn1615-5742
dc.identifier.issue4
dc.identifier.pmid35316607
dc.identifier.scopus2-s2.0-85126880664
dc.identifier.scopusqualityQ2
dc.identifier.startpage470
dc.identifier.urihttps://doi.org/10.1177/10935266221077572
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25635
dc.identifier.volume25
dc.identifier.wosWOS:000774051300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofPediatric and Developmental Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectcolchicine; familial mediterranean fever; celiac disease; histopathology
dc.titleThe Effects of Colchicine on the Histopathological Findings of Celiac Disease During Familial Mediterranean Fever Treatment
dc.typeArticle

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