Serum pentraxin-3 levels and flow-mediated dilation in dipper and non-dipper hypertension
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background Endothelial dysfunction is one of the main pathological processes of hypertension. The association of serum pentraxin-3 (PTX3) levels and endothelial dysfunction becomes a more interesting scientific research issue due to high potential of PTX3 as a diagnostic and prognostic biomarker. We aimed to investigate the relationship between serum PTX3 levels and flow-mediated dilation results in patients with dipper and non-dipper hypertension. Methods This study included 90 hypertensive patients were divided into two groups based on 24 hours ambulatory blood pressure monitoring (ABPM): 38 patients with a dipper pattern and 52 patients with non-dipper pattern. Noninvasive evaluation of the endothelial functions was performed using flow-mediated dilation (FMD) method. Results Serum pentraxin-3 levels were higher in patients with non-dipper HT compared to dipper hypertension (P = 0.028). In addition, we found negative correlation between serum PTX3 and FMD basal/FMD hyperemia ratio (r = -0.297, P = 0.05 for FMD basal/FMD hyperemia ratio, respectively). Conclusions Serum PTX3 levels are closely related with the measures of indirect noninvasive evaluation methods (FMD) in both DH and NDH patients.
Açıklama
Demir, Vahit/0000-0001-8349-6651; KISA, Ucler/0000-0002-8131-6810; Alp, Caglar/0000-0001-5984-1857
Anahtar Kelimeler
ambulatory blood pressure monitoring, dipper hypertension, flow-mediated dilation, non-dipper hypertension, pentraxin-3
Kaynak
Journal Of Clinical Laboratory Analysis
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
33
Sayı
3
Künye
Alp Ç, Dogru MT, Karadeniz M, Sarak T, Demir V, Çelik Y, Kandemir H, Kısa Ü. Serum pentraxin-3 levels and flow-mediated dilation in dipper and non-dipper hypertension. J Clin Lab Anal. 2019 Mar;33(3):e22718.
