Serum pentraxin-3 levels and flow-mediated dilation in dipper and non-dipper hypertension

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dc.contributor.authorAlp, Caglar
dc.contributor.authorDogru, Mehmet Tolga
dc.contributor.authorKaradeniz, Muhammed
dc.contributor.authorSarak, Taner
dc.contributor.authorDemir, Vahit
dc.contributor.authorCelik, Yunus
dc.contributor.authorKisa, Ucler
dc.date.accessioned2020-06-25T18:34:15Z
dc.date.available2020-06-25T18:34:15Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionDemir, Vahit/0000-0001-8349-6651; KISA, Ucler/0000-0002-8131-6810; Alp, Caglar/0000-0001-5984-1857
dc.description.abstractBackground Endothelial dysfunction is one of the main pathological processes of hypertension. The association of serum pentraxin-3 (PTX3) levels and endothelial dysfunction becomes a more interesting scientific research issue due to high potential of PTX3 as a diagnostic and prognostic biomarker. We aimed to investigate the relationship between serum PTX3 levels and flow-mediated dilation results in patients with dipper and non-dipper hypertension. Methods This study included 90 hypertensive patients were divided into two groups based on 24 hours ambulatory blood pressure monitoring (ABPM): 38 patients with a dipper pattern and 52 patients with non-dipper pattern. Noninvasive evaluation of the endothelial functions was performed using flow-mediated dilation (FMD) method. Results Serum pentraxin-3 levels were higher in patients with non-dipper HT compared to dipper hypertension (P = 0.028). In addition, we found negative correlation between serum PTX3 and FMD basal/FMD hyperemia ratio (r = -0.297, P = 0.05 for FMD basal/FMD hyperemia ratio, respectively). Conclusions Serum PTX3 levels are closely related with the measures of indirect noninvasive evaluation methods (FMD) in both DH and NDH patients.en_US
dc.identifier.citationAlp Ç, Dogru MT, Karadeniz M, Sarak T, Demir V, Çelik Y, Kandemir H, Kısa Ü. Serum pentraxin-3 levels and flow-mediated dilation in dipper and non-dipper hypertension. J Clin Lab Anal. 2019 Mar;33(3):e22718.en_US
dc.identifier.doi10.1002/jcla.22718
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue3en_US
dc.identifier.pmid30411809
dc.identifier.scopus2-s2.0-85056310757
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/jcla.22718
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7839
dc.identifier.volume33en_US
dc.identifier.wosWOS:000461886300017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Clinical Laboratory Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectambulatory blood pressure monitoringen_US
dc.subjectdipper hypertensionen_US
dc.subjectflow-mediated dilationen_US
dc.subjectnon-dipper hypertensionen_US
dc.subjectpentraxin-3en_US
dc.titleSerum pentraxin-3 levels and flow-mediated dilation in dipper and non-dipper hypertensionen_US
dc.typeArticle

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