Helicobacter pylori resistance to clarithromycin and fluoroquinolones in a pediatric population in Turkey: A cross-sectional study

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dc.contributor.authorGuven, Burcu
dc.contributor.authorGulerman, Fulya
dc.contributor.authorKacmaz, Birgul
dc.date.accessioned2020-06-25T18:34:02Z
dc.date.available2020-06-25T18:34:02Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackgroundHelicobacter pylori antimicrobial resistance is gradually increasing around the world. However, there are a limited number of studies reporting on this issue in the pediatric population. In this study, we aimed to determine Hpylori resistance to clarithromycin and fluoroquinolones in the pediatric patients living in Krkkale province that were detected with Hpylori in gastric biopsies. Moreover, we also aimed to investigate the concordance between the histopathologic and molecular methods used in the diagnosis of Hpylori infection. Materials and MethodsPatients aged 2-18years who had a history of epigastric pain and/or nausea persisting for longer than 1month underwent upper gastrointestinal endoscopy. Biopsies were taken from the gastric antral mucosa. In the samples detected with Hpylori in the histopathologic examination, the presence of Hpylori and Hpylori resistance to clarithromycin and fluoroquinolones was investigated using the GenoType HelicoDR test which allows the detection of wild-type and mutant genes. The strains detected with more than one mutant gene are defined as hetero-resistant strains. ResultsThe 93 patients that underwent DNA extraction and amplification included 68 (73.1%) girls and 25 (26.9%) boys with a median age of 152.62 (range 6-17) years. The overall concordance for the diagnosis of Hpylori infection between histopathology and PCR was 94%, and Hpylori resistance to clarithromycin and fluoroquinolones was 27% and 15%, respectively. ConclusionsThe high Hpylori resistance to clarithromycin and fluoroquinolones among the pediatric patients in our region implicates that the antibiotic sensitivity of strains should be studied prior to administration in accordance with the recommendations provided in the guidelines. Moreover, the presence of hetero-resistant strains in our patients may be a reason for treatment failure.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/hel.12581
dc.identifier.issn1083-4389
dc.identifier.issn1523-5378
dc.identifier.issue3en_US
dc.identifier.pmid30950125
dc.identifier.scopus2-s2.0-85063886624
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/hel.12581
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7773
dc.identifier.volume24en_US
dc.identifier.wosWOS:000469090700010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofHelicobacter
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchildrenen_US
dc.subjectclarithromycinen_US
dc.subjectfluoroquinoloneen_US
dc.subjectresistanceen_US
dc.titleHelicobacter pylori resistance to clarithromycin and fluoroquinolones in a pediatric population in Turkey: A cross-sectional studyen_US
dc.typeArticle

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