Effects of low-dose methotrexate in spinal cord injury in rats

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dc.contributor.authorBakar, Bulent
dc.contributor.authorKose, Emine Arzu
dc.contributor.authorKupana Ayva, Sebnem
dc.contributor.authorSarkarati, Bahram
dc.contributor.authorKasimcan, Mustafa Omur
dc.contributor.authorKilinc, Kamer
dc.date.accessioned2020-06-25T18:07:10Z
dc.date.available2020-06-25T18:07:10Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBACKGROUND This study was designed to evaluate the possible protective effects of low-dose methotrexate in the spinal cord injury (SCI) in rats. METHODS Thirty-seven Wistar albino rats were used in the present study. Except for the animals of the Sham group, all animals were divided into two main groups, which were used in acute and subacute stage investigations. Then, thoracal laminectomy was performed, and except for the Sham group, SCI was induced using a temporary aneurysm clip. After clip compression, the experimental material (methotrexate or methylprednisolone) was administered intraperitoneally, except in the Sham and Control groups. Then, the spinal cords were removed to evaluate the SCI histopathologically and biochemically at the scheduled date. RESULTS Neither experimental material was shown to reduce the histopathological grade in either stage of SCI. Low-dose methotrexate was shown to decrease lipid peroxidation levels only in the subacute stage of SCI. However, methylprednisolone and low-dose methotrexate could not decrease or block myeloperoxidase enzyme activation in either stage of SCI. CONCLUSION Low-dose methotrexate was effective in reducing the lipid peroxidation levels in the subacute stage of SCI, although histopathological evaluation results and myeloperoxidase levels of all groups did not support this finding at either stage.en_US
dc.identifier.citationBakar B., Köse E. A., Ayva Ş. K., Sarkaratı B., Kasımcan M. Ö., Kılınç K. (2013). Effects of low-dose methotrexate in spinal cord injury in rats. Ulusal Travma ve Acil Cerrahi Dergisi, 19(4), 285 - 293.en_US
dc.identifier.doi10.5505/tjtes.2013.65475
dc.identifier.endpage293en_US
dc.identifier.issn1306-696X
dc.identifier.issue4en_US
dc.identifier.pmid23884668
dc.identifier.scopus2-s2.0-84880112654
dc.identifier.scopusqualityQ3
dc.identifier.startpage285en_US
dc.identifier.trdizinid152408
dc.identifier.urihttps://doi.org/10.5505/tjtes.2013.65475
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5500
dc.identifier.volume19en_US
dc.identifier.wosWOS:000322097200002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLow-dose methotrexateen_US
dc.subjectmethylprednisoloneen_US
dc.subjectspinal cord injuryen_US
dc.titleEffects of low-dose methotrexate in spinal cord injury in ratsen_US
dc.typeArticle

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