Protective effects of trapidil in lung after abdominal aorta induced ischemia-reperfusion injury: an experimental study

dc.contributor.authorSomuncu, S
dc.contributor.authorCakmak, M
dc.contributor.authorErdogan, S
dc.contributor.authorCaglayan, O
dc.contributor.authorCaglayan, F
dc.contributor.authorAkman, H
dc.contributor.authorKaya, M
dc.date.accessioned2020-06-25T17:40:18Z
dc.date.available2020-06-25T17:40:18Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractWe aimed to investigate the protective effects of trapidil after the occlusion of abdominal aorta and the reperfusion injury in lung. Eighteen New Zealand albino rabbits were used in the study. In six animals [group 1, ischemia-reperfusion (IR) group], the abdominal aorta was exposed and a microvascular clamp was placed in the infrarenal abdominal aorta for 60 min. After the ischemic period, the microvascular clamp was removed and reperfusion was provided for 2 h. After the reperfusion period, the lungs were removed carefully and specimens were prepared for histopathological and biochemical studies in appropriate conditions. In group 2 (study group), trapidil (Rocarnal, Rentschler-UCB GmbH, Kerpen, Germany) was administered intraperitoneally as a single dose 1 h prior to trial, the IR procedure was performed and lung specimens were prepared similar to group 1. In group 3 (sham group), the infrarenal abdominal aorta was exposed and lung specimens were prepared for histopathological and biochemical studies at the end of the study. Histopathological changes, malondialdehyde (MDA), nitric oxide (NO) and total sulfhydryl group (T-SH) levels were evaluated. There was a statistical difference between the IR group and study group regarding NO and MDA levels (P < 0.05 and P < 0.01, respectively), but this was not detected between the IR group and the sham group (P > 0.05). There was no statistical difference among the three groups regarding T-SH levels (P > 0.05). While a statistical difference was found between the sham group and study group in the NO level (P < 0.05), no statistical difference was found in the MDA level (P > 0.05). There was a statistical difference in interstitial edema, PMN infiltration and hemorrhage scores among the groups (P < 0.05). There was a statistical difference between the IR group and study group in PMN infiltration (P < 0.05), but this was not detected between the groups in interstitial edema and hemorrhage scores (P > 0.05). There was a statistical difference between IR group and sham group in interstitial edema, PMN infiltration and hemorrhage scores (P < 0.05). Statistical difference was found between the sham group and study group in interstitial edema and hemorrhage scores (P < 0.05), but not in PMN infiltration (P > 0.05). Conclusions: Infrarenal abdominal aortic occlusion and reperfusion causes lung injury. We conclude that trapidil has preventive effects in the lung tissue after IR injury.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00383-005-1542-2
dc.identifier.endpage988en_US
dc.identifier.issn0179-0358
dc.identifier.issue12en_US
dc.identifier.pmid16244863
dc.identifier.scopus2-s2.0-28344448446
dc.identifier.scopusqualityQ2
dc.identifier.startpage983en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-005-1542-2
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3383
dc.identifier.volume21en_US
dc.identifier.wosWOS:000233630000008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjecttrapidilen_US
dc.subjectlungen_US
dc.titleProtective effects of trapidil in lung after abdominal aorta induced ischemia-reperfusion injury: an experimental studyen_US
dc.typeArticle

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