Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study

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dc.contributor.authorAriturk, Ozlem Karakurt
dc.contributor.authorUreten, Kemal
dc.contributor.authorSari, Munevver
dc.contributor.authorYazihan, Nuray
dc.contributor.authorErmis, Ezgi
dc.contributor.authorErguder, Imge
dc.date.accessioned2020-06-25T18:07:12Z
dc.date.available2020-06-25T18:07:12Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionYazihan, Nuray/0000-0003-1237-8468
dc.description.abstractObjective: There are many studies demonstrating deteriorated ventricle and endothelium functions in familial Mediterranean fever (FMF) patients. As FMF is an autoinflammatory disease with an ongoing inflammatory activity and inflammation plays an important role in the development and progression of atherosclerosis in some of the rheumatic diseases, we aimed to investigate the early markers of atherosclerosis in patients with FMF by the measurements of serum paraoxonase-1 (PON-1) activity mean platelet volume (MPV) and malondialdehyde (MDA) level. Methods: This study is a cross-sectional, observational study. Forty consecutive patients with FMF and twenty healthy volunteers were selected to form the study population. The diagnosis of FMF was based on Tel-Hashomer criteria. Serum PON-1 activity, MPV and MDA level were determined to examine their association with FMF. Student's t-test, Mann-Whitney U test, Pearson correlation analysis were used for statistical analysis. Results: The mean PON-1 activity in FMF patients was significantly lower than in the healthy population (141.46 +/- 38.29 vs. 179.62 +/- 10.73 U/I, p<0.01). Serum MDA levels were the same between the groups (1.08 +/- 0.66 vs. 1.08 +/- 0.33 nmol/mL, p=0.99). MPV was higher in FMF patients than in the control I group (8.87 +/- 0.99 vs. 8.22 +/- 0.45 fl, p=0.04). PUN, MPV and MDA levels were the same in FMF patients with acute attack and attack -free period. Conclusion: Our results show that PON-1 activity is lower in patients with FMF. Reduced PON-1 activity and increased MPV, independent of the oxidative stress status of these patients, may lead to increased atherosclerotic propensity in FMF.en_US
dc.identifier.citationKarakurt Ö. A., Üreten K., Sari M., Yazıhan N., Ermiş E., Ergüder B. İ. (2013). Relationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational study. Anadolu Kardiyoloji Dergisi, 13(4), 357 - 362.en_US
dc.identifier.doi10.5152/akd.2013.103
dc.identifier.endpage362en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue4en_US
dc.identifier.pmid23531873
dc.identifier.scopus2-s2.0-84879268912
dc.identifier.scopusqualityN/A
dc.identifier.startpage357en_US
dc.identifier.trdizinid155461
dc.identifier.urihttps://doi.org/10.5152/akd.2013.103
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5510
dc.identifier.volume13en_US
dc.identifier.wosWOS:000322679800010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal Of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectatherosclerosisen_US
dc.subjectparaoxonaseen_US
dc.subjectmean platelet volumeen_US
dc.subjectmalondialdehydeen_US
dc.titleRelationship of paraoxonase-1, malondialdehyde and mean platelet volume with markers of atherosclerosis in familial Mediterranean fever: an observational studyen_US
dc.typeArticle

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