The diagnostic value of neurogranin in patients with carbon monoxide poisoning: Can it show early neurological damage?

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dc.authoridVural, Sevilay/0000-0002-1722-7987
dc.contributor.authorYesilyurt, Omer
dc.contributor.authorComertpay, Ertan
dc.contributor.authorVural, Sevilay
dc.contributor.authorEroglu, Oguz
dc.contributor.authorBadem, Nermin Dindar
dc.contributor.authorCankaya, Imran
dc.contributor.authorBilgili, Yasemin Karadeniz
dc.date.accessioned2025-01-21T16:44:58Z
dc.date.available2025-01-21T16:44:58Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and aim: Carbon monoxide poisoning is a toxicological emergency that causes neurological complications. High serum neurogranin can be detected in acute or chronic conditions where brain tissue is damaged. This study aimed to investigate the diagnostic value of serum neurogranin level and its role in demonstrating neurological damage in patients admitted to the emergency department with carbon monoxide poisoning. Materials and methods: The study was conducted prospectively on patients with carbon monoxide poisoning (patient group) and healthy volunteers (control group). Demographic characteristics and scrum neurogranin level of all participants and symptoms at admission, neurological examination findings, laboratory results, and Diffusion-Weighted Magnetic Resonance Imaging results of the patient group were recorded. We used an independent sample t-test to compare neurogranin levels and bivariate correlation analysis to compare the relationship between serum neurogranin levels and data belonging to the patient group. Results: Sixty eight participants (patient group, n- 36; control group, n- 32) were included in the study. Serum neurogranin level was significantly higher in patients with carbon monoxide poisoning (0.31 +/- 0.16 ng/ml) compared to control group (0.22 +/- 0.10 ng/ml) (p = 0.015). The mean Glasgow Coma Scale of the patients with carbon monoxide poisoning was 14.59 +/- 0.23, and of Diffusion Weighted Magnetic Resonance Imaging results were completely normal in 94.4% (n = 34). There was no correlation between serum neurogranin level and Diffusion Weighted Magnetic Resonance Imaging results (r = -0.011; p = 0.953). Conclusion: Serum neurogranin level may be a new diagnostic biomarker in patients admitted to the emergency department with carbon monoxide poisoning. The high serum neurogranin levels detected in patients with normal diffusion-weighted imaging after carbon monoxide poisoning suggest that there is neurological damage in these patients, even if imaging methods cannot detect it. (C) 2021 Elsevier Inc. All rights reserved.
dc.description.sponsorshipKirikkale University [2019/003]
dc.description.sponsorshipThis work is funded by Kirikkale University Scientific Research Project support (project no. 2019/003).
dc.identifier.doi10.1016/j.ajem.2021.07.052
dc.identifier.endpage195
dc.identifier.issn0735-6757
dc.identifier.issn1532-8171
dc.identifier.pmid34388687
dc.identifier.scopus2-s2.0-85112030038
dc.identifier.scopusqualityQ1
dc.identifier.startpage191
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2021.07.052
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25564
dc.identifier.volume50
dc.identifier.wosWOS:000705407400036
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Inc
dc.relation.ispartofAmerican Journal of Emergency Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectCarbon monoxide poisoning; Diffusion weighted magnetic resonance; imaging; Neurogranin
dc.titleThe diagnostic value of neurogranin in patients with carbon monoxide poisoning: Can it show early neurological damage?
dc.typeArticle

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