A new inflammatory marker in overweight patients: triggering receptor expressed on myeloid cells-1

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dc.contributor.authorCifci, A.
dc.contributor.authorCeylan, Durmaz S.
dc.contributor.authorOklu, K.
dc.contributor.authorGungunes, A.
dc.contributor.authorKatar, D.
dc.contributor.authorKarahan, I
dc.contributor.authorBoyunaga, H.
dc.date.accessioned2021-01-14T18:11:05Z
dc.date.available2021-01-14T18:11:05Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionkarahan, irfan/0000-0003-4669-1751
dc.description.abstractBACKGROUND: Triggering receptor expressed on myeloid cells 1 (TREM-1) is secreted by phagocytes in adipose tissue and it also upregulates the expression of genes involved in the inflammatory response and atherosclerotic conditions. This study was aimed to investigate the serum TREM-1 levels in overweight patients. METHODS: Twenty-eight subjects in the overweight group (OG) and 20 age-matched healthy subjects in the control group (CG) (BMI 27.6 +/- 1.2 vs 23.1 +/- 2.17 kg/m(2), respectively, p< 0.001) were included in the study. The serum sTREM-1 level was measured by ELISA. The homeostasis model assessment score (HOMA-IR) was also calculated. RESULTS: The mean TREM-1 levels were significantly higher in OG than in CG (407.3 +/- 323.7 vs 150.3 +/- 152.7 pg/mL, respectively, p< 0.001). The HOMA-IR score was also significantly higher in OG than in CG (3.42 +/- 3.63 vs 2.77 +/- 1.61, respectively). A positive correlation was detected between TREM-1 and BMI (r= 0.318, p= 0.028). CONCLUSIONS: This study mainly demonstrated that a high serum TREM-1 level might be an early inflammatory marker in overweight patients. We found that TREM-1 might be associated with BMI in overweight patients regardless of insulin resistance (Tab. 1, Ref. 21). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2020_039
dc.identifier.endpage262en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue4en_US
dc.identifier.pmid32356439
dc.identifier.scopus2-s2.0-85087043375
dc.identifier.scopusqualityQ2
dc.identifier.startpage259en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2020_039
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12875
dc.identifier.volume121en_US
dc.identifier.wosWOS:000530579700002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTREM-1en_US
dc.subjectinsulin resistanceen_US
dc.subjectoverweight subjectsen_US
dc.titleA new inflammatory marker in overweight patients: triggering receptor expressed on myeloid cells-1en_US
dc.typeArticle

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