Effect of nitrogen mustard, a vesicant agent, on lymphocyte energy metabolism

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dc.contributor.authorKenar, Levent
dc.contributor.authorBoyunağa, Hakan
dc.contributor.authorSerdar, Muhittin
dc.contributor.authorKarayilanoğlu, Turan
dc.contributor.authorErbil, M. Kemal
dc.date.accessioned2020-06-25T17:41:24Z
dc.date.available2020-06-25T17:41:24Z
dc.date.issued2006
dc.descriptionSERDAR, Muhittin A./0000-0002-3014-748X
dc.description.abstractBackground: The vesicant agents sulfur and nitrogen mustards, which contain chloroethyl groups, are potent inhibitors of DNA synthesis and cell growth, likely changing the utilization of anaerobic glycolysis for energy generation. Methods: To investigate the effect of nitrogen mustard on cellular energy metabolism, lymphocytes treated with increasing doses of mechlorethamine (HN2), a nitrogen mustard and an analogue of sulfur mustard, were incubated with radiolabeled glucose. The rates of aerobic and anaerobic glycolysis were then determined. Results: Glycogen consumption was significantly higher in cells treated with HN2 in a dose-dependent manner compared to untreated cells. Similarly, the amount of end-product lactate was increased, but CO2 was reduced in HN2-treated cells. Conclusions: Lymphocytes normally use aerobic glycolysis under aerobic conditions, but energy metabolism predominantly involved anaerobic glycolysis after severe intoxication with mustard agent.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1515/CCLM.2006.220
dc.identifier.endpage1257en_US
dc.identifier.issn1434-6621
dc.identifier.issn1437-4331
dc.identifier.issue10en_US
dc.identifier.pmid17032138
dc.identifier.scopus2-s2.0-33750081775
dc.identifier.scopusqualityQ1
dc.identifier.startpage1253en_US
dc.identifier.urihttps://doi.org10.1515/CCLM.2006.220
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3705
dc.identifier.volume44en_US
dc.identifier.wosWOS:000241193900013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofClinical Chemistry And Laboratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectenergy metabolismen_US
dc.subjectglycogen degradationen_US
dc.subjectglycolysisen_US
dc.subjectmechlorethamineen_US
dc.subjectmustarden_US
dc.titleEffect of nitrogen mustard, a vesicant agent, on lymphocyte energy metabolismen_US
dc.typeArticle

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