Effect of hypothermia on apoptosis in traumatic brain injury and hemorrhagic shock model

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dc.contributor.authorEroglua, Oguz
dc.contributor.authorDeniz, Turgut
dc.contributor.authorKisa, Ucler
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorAydinuraz, Kuzey
dc.date.accessioned2020-06-25T18:22:36Z
dc.date.available2020-06-25T18:22:36Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractIntroduction: The neuroprotective mechanisms of therapeutic hypothermia against trauma-related injury have not been fully understood yet. In this study, we aimed to investigate the effects of therapeutic hypothermia on biochemical and histopathological markers of apoptosis using Traumatic brain injury (TBI) and hemorrhagic shock (HS) model. Methods: A total of 50 male albino-wistar rats were divided into five groups: Group isolated TBI, Group NT (HT + HS + normothermia), Group MH (HT + HS + mild hypothermia), Group MoH (HT + HS + moderate hypothermia) and Group C (control). Neurological deficit scores were assessed at baseline and at 24 h. The rats were, then, sacrificed to collect serum and brain tissue samples. Levels of Caspase-3,6,8, proteoglycan-4 (PG-4), malondialdehyde (MDA), and nitric oxide (NO) were measured in serum and brain tissue samples. Histopathological examination was performed in brain tissue. Results: There were significant differences in the serum levels of Caspase-3 between Group NT and Group C (p = 0.018). The serum levels of Caspase-6 in Group NT (0.70 +/- 0.58) were lower than Group MH (1.39 +/- 0.28), although the difference was not statistically significant (p = 0.068). There were significant differences in the brain tissue samples for Caspase-3 levels between Group NT and Group C (p = 0.049). A significant difference in the Caspase-8 brain tissue levels was also observed between Group NT and Group C (p = 0.022). Group NT had significantly higher scores of all the pathological variables (for edema p < 0.017; for gliosis p < 0.001; for congestion p < 0.003, for hemorrhage p < 0.011) than Group C. Conclusion: Our study results suggest that hypothermia may exert its neuroprotective effects by reducing markers of apoptotic pathway, particularly Caspase-3 on TBI and HS. (c) 2017 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.injury.2017.09.032
dc.identifier.endpage2682en_US
dc.identifier.issn0020-1383
dc.identifier.issn1879-0267
dc.identifier.issue12en_US
dc.identifier.pmid29061477
dc.identifier.scopus2-s2.0-85031732210
dc.identifier.scopusqualityQ1
dc.identifier.startpage2675en_US
dc.identifier.urihttps://doi.org/10.1016/j.injury.2017.09.032
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6822
dc.identifier.volume48en_US
dc.identifier.wosWOS:000418074900009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInjury-International Journal Of The Care Of The Injured
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnimal studyen_US
dc.subjectCaspaseen_US
dc.subjectExperimentalen_US
dc.subjectHemorrhagic shocken_US
dc.subjectTraumatic brain injuryen_US
dc.subjectHypothermiaen_US
dc.subjectProteoglycan-4en_US
dc.titleEffect of hypothermia on apoptosis in traumatic brain injury and hemorrhagic shock modelen_US
dc.typeArticle

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