Investigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsion

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dc.contributor.authorYuvanc, Ercan
dc.contributor.authorTuglu, Devrim
dc.contributor.authorOzan, Tunc
dc.contributor.authorKisa, Ucler
dc.contributor.authorBalci, Mahi
dc.contributor.authorBatislam, Ertan
dc.contributor.authorYilmaz, Erdal
dc.date.accessioned2020-06-25T18:29:43Z
dc.date.available2020-06-25T18:29:43Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractPurpose: To investigate the biochemical, histopathologic, and spermatogenetic changes in the detorsionated testicle after experimental torsion and to study the antioxidant effects of pheniramine maleate and nebivolol. Methods: Twenty-four Sprague-Dawley male rats were divided into 4 groups: Group 1: Sham; Group 2: Torsion/Detorsion (T/D); Group 3: T/D + Pheniramine maleate (PM); Group 4: T/D + Nebivolol (NB) group. Paroxanase (PON), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stres index (OSI) were measured, and spermatogenetic and histopathologic evaluation was performed in tissue and blood samples. Results: The evaluation of tissue TAS indicated no statistically significant difference in Group 3 compared to Group 2. A statistically significant increase was detected in Group 4 compared to Group 2. Serum PON levels revealed a statistically significant increase in Groups 3 and 4 compared to Groups 1 and 2. The Johnsen testicular biopsy score decreased in Groups 3 and 4, but the decrease was not statistically significant. Conclusions: Pheniramine maleate and nebivolol have antioxidant effects against ischemia-reperfusion damage. They also support tissue recovery, which is more significantly observed by nebivolol.en_US
dc.identifier.citationYuvanc, E., Tuglu, D., Ozan, T., Kisa, U., Balci, M., Batislam, E., & Yilmaz, E. (2018). Investigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsion. Acta cirurgica brasileira, 33(2), 125–133.en_US
dc.identifier.doi10.1590/s0102-865020180020000004
dc.identifier.endpage133en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue2en_US
dc.identifier.pmid29513811
dc.identifier.scopus2-s2.0-85042903959
dc.identifier.scopusqualityQ2
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1590/s0102-865020180020000004
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7437
dc.identifier.volume33en_US
dc.identifier.wosWOS:000426974600004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTestisen_US
dc.subjectSpermatic Cord Torsionen_US
dc.subjectPheniramineen_US
dc.subjectNebivololen_US
dc.subjectOxidative Stressen_US
dc.subjectRatsen_US
dc.titleInvestigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsionen_US
dc.typeArticle

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