Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features

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dc.contributor.authorKültür, Turgut
dc.contributor.authorZengin, Mehmet
dc.date.accessioned2025-01-21T16:34:19Z
dc.date.available2025-01-21T16:34:19Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: This study aims to investigate the relationship between estrogen receptors (ERs) and progesterone receptors (PRs) and histopathological findings in synovial tissue in rheumatoid arthritis (RA) and osteoarthritis (OA) patients. Patients and methods: Synovial tissue samples obtained from synovial surgery from 30 RA (10 males, 20 females) and 92 OA (27 males, 65 females) patients with median age of 59 (range, 50 to 67) years were analyzed retrospectively between January 2010 and January 2019. The relationship between histopathological features and hormone receptor presence was analyzed. Results: There was a meaningful relationship between histopathological parameters and RA and OA (p=0.01). The sex hormone receptor's presence was significantly higher in females with RA (p=0.01). Additionally, in the RA group, there was a remarkable relationship between ER and focal aggregates of lymphocytes (p=0.01), perivascular infiltrates of lymphocytes (p=0.03), and diffuse infiltrates of lymphocytes (p= 0.01). In the OA group, a significant relationship was observed between PR and subchondral inflammation (p=0.01). In multivariate analysis, it was observed that ER was an independent risk factor for focal aggregates of lymphocytes in RA group (odds ratio [OR]=1.51 [1.02-2.25], p=0.04). Besides, PR was found to be an independent risk factor for subchondral inflammation in OA group (OR=3.90 [1.28-11.80], p= 0.02). Conclusion: The presence of the sex hormone receptor in the synovium may change histopathological features and affect the clinical course.
dc.identifier.doi10.46497/ArchRheumatol.2021.8242
dc.identifier.endpage200
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.issue2
dc.identifier.pmid34527923
dc.identifier.scopus2-s2.0-85107817137
dc.identifier.scopusqualityQ3
dc.identifier.startpage192
dc.identifier.trdizinid445748
dc.identifier.urihttps://doi.org/10.46497/ArchRheumatol.2021.8242
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay445748
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23942
dc.identifier.volume36
dc.identifier.wosWOS:000657513700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish League Against Rheumatism
dc.relation.ispartofArchives of Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectEstrogen receptors; histopathological findings; osteoarthritis; progesterone receptors; rheumatoid arthritis
dc.titlePatients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features
dc.typeArticle

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