Inhibitory effect of Bisphenol A on in vitro feline uterine contractions

Basit Öğe Kaydı
dc.contributor.authorKabakci, Ruhi
dc.contributor.authorMacun, Hasan Ceyhun
dc.contributor.authorPolat, Ibrahim Mert
dc.contributor.authorYildirim, Ebru
dc.date.accessioned2020-06-25T18:34:02Z
dc.date.available2020-06-25T18:34:02Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionKABAKCI, Ruhi/0000-0001-9131-0933
dc.description.abstractBisphenol A (BPA) is an environmental pollutant used as a plasticizer in the manufacture of many plastic products, such as packaging, containers, and water and beverage bottles. There are deleterious effects of BPA on metabolic, endocrine, nervous, and reproductive systems. This is the first study in which there was investigation of the in vitro effect of BPA on the spontaneous contractions of the cat uterus. The tubal uterine segments (1 cm) collected from queens in estrus were suspended in an isolated organ bath. Following tissue stabilization, spontaneous contractions were recorded for 10 min to constitute the control group. The effects of the solvent (alcohol) and BPA at different concentrations (1, 10, and 100 mu M) on uterine contractions were subsequently evaluated at 10 min intervals in terms of frequency and mean amplitude variables. The ethanol vehicle did not alter the uterine contractions compared to the control group. All concentrations of BPA used in the study resulted in a reduction (P < 0.05) in amplitude of uterine contractions in a dose-dependent manner, while only the largest dose of BPA decreased the frequency of contractions (P < 0.05). In reproductive physiology, regular uterine contractions facilitate successful fertilization, migration, implantation, and maintenance of pregnancy, as well as fetus expulsion. The results of this study indicate BPA has an inhibitory effect on spontaneous contractions of the cat uterus. It is proposed that this suppressive effect of BPA on uterine contractions might lead to queen infertility.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.anireprosci.2019.03.017
dc.identifier.endpage33en_US
dc.identifier.issn0378-4320
dc.identifier.issn1873-2232
dc.identifier.pmid30967318
dc.identifier.scopus2-s2.0-85063791127
dc.identifier.scopusqualityQ1
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.1016/j.anireprosci.2019.03.017
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7772
dc.identifier.volume205en_US
dc.identifier.wosWOS:000469907300004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofAnimal Reproduction Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBPAen_US
dc.subjectCatsen_US
dc.subjectFeline uterusen_US
dc.subjectSpontaneous contractionen_US
dc.titleInhibitory effect of Bisphenol A on in vitro feline uterine contractionsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Inhibitory effect of Bisphenol A on in vitro feline uterine contractions.pdf
Boyut:
528.81 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu