Melanocytes as the source of the increased melanisation in pigmented epithelial tumours: a holistic approach

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dc.contributor.authorKilitci, Asuman
dc.contributor.authorElmas, Omer Faruk
dc.contributor.authorAkdeniz, Necmettin
dc.contributor.authorGamsizkan, Mehmet
dc.date.accessioned2025-01-21T16:34:52Z
dc.date.available2025-01-21T16:34:52Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: We aimed to elucidate the causes of the increased melanisation in basal cell carcinoma (BCC) and seborrheic keratosis (SK), and the role of melanocytes in this process. Materials and methods: This study was a retrospective-cohort study conducted in the pathology department of a university hospital between January 2019 and October 2020. Forty-nine SK and 30 pigmented BCC were included in our study. SRY-box transcription factor 10 (SOX10), CD68, and Masson???Fontana staining was used for analysis in all samples. A representative section of each specimen was photographed under ??400 magnification to facilitate the assessments of the morphology of the melanocytes and their following morphometric parameters: density, nuclear diameter, and distribution. The density of pigmented keratinocytes in the lesional epidermis was scored. The nuclear diameters of melanocytes located in the nonlesional epidermis, the density of the melanophages, and the presence or absence of ulceration and solar elastosis were also recorded. Results: The morphometric findings confirmed a statistically significant increase in melanocyte density in the BCC group compared with that in the SK group (p < 0.001). Moreover, the nuclear minor diameters in the melanocytes of the BCC sections were significantly higher than those in the SK specimens (p < 0.001). The epidermal melanocytes were distributed diffusely in almost all BCC specimens (96.7%), whereas they were mainly limited to the basal layer in the majority of the SK sections (59.2%). The number of epidermal melanised keratinocytes with a score of 3 was significantly higher in the SK group (n = 31; 63.2%) than in the BCC group (n = 6; 20%) (p = 0.001), and they were the main cells representing the pigmented appearance of the tumours. No significant difference was found between both tumour groups in terms of their melanophage density scores (p = 0.206). Conclusion: This study is the first step towards an objective quantification of the melanocytes in pigmented epithelial tumours and may provide a morphological background for future studies on these skin lesions.
dc.identifier.doi10.55730/1300-0144.5362
dc.identifier.endpage698
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3
dc.identifier.pmid36326339
dc.identifier.scopus2-s2.0-85135214160
dc.identifier.scopusqualityQ1
dc.identifier.startpage691
dc.identifier.trdizinid536373
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5362
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay536373
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24016
dc.identifier.volume52
dc.identifier.wosWOS:000816957200020
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectPigmentation; melanisation; basal cell carcinoma; seborrheic keratosis; SOX10
dc.titleMelanocytes as the source of the increased melanisation in pigmented epithelial tumours: a holistic approach
dc.typeArticle

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