Nonfunctional adrenal incidentalomas may be related to bisphenol-A

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dc.contributor.authorEker, Fatih
dc.contributor.authorGungunes, Askin
dc.contributor.authorDurmaz, Senay
dc.contributor.authorKisa, Ucler
dc.contributor.authorCelik, Zeynep Rumeysa
dc.date.accessioned2021-01-14T18:10:23Z
dc.date.available2021-01-14T18:10:23Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractPurpose Bisphenol-A (BPA) is an endocrine-disrupting chemical that may affect the hormones and their receptors. The aim of this study is to determine whether BPA has an effect on the development of nonfunctional adrenal incidentaloma (NFAI). Methods Fifty patients who were admitted to endocrinology outpatient clinics and diagnosed as NFAI were included in the study. Fifty healthy people without adrenal mass and adrenal pathology in the upper abdominal computerized tomography or magnetic resonance imaging were also included as control group. Age, gender and body mass index of the study groups were similar. The serum samples for BPA were stored at -80 degrees C in refrigerator until working in the lab. Serum BPA levels were measured using ELISA technique. Results Mean serum BPA level was 7.06 +/- 3.96 ng/ml in NFAI patients and 4.79 +/- 3.01 ng/ml in control group. Serum BPA level was significantly higher in NFAI group than control group (p = 0.001). Serum BPA levels were also found to be significantly higher in women with NFAI than in men with NFAI (p = 0.019). Conclusions The mechanisms of NFAI development have not been clarified yet. Increased BPA exposure with developed industrialization may play a role in NFAI formation. For the reduction of BPA exposure, the use of plastic prepacked products, plastic containers, and safety measures are essential for public health.en_US
dc.identifier.citationEker, F., Gungunes, A., Durmaz, S. et al. Nonfunctional adrenal incidentalomas may be related to bisphenol-A. Endocrine 71, 459–466 (2021).en_US
dc.identifier.doi10.1007/s12020-020-02502-2
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.pmid32965630
dc.identifier.scopus2-s2.0-85091438083
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s12020-020-02502-2
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12567
dc.identifier.wosWOS:000572340200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSPRINGERen_US
dc.relation.ispartofENDOCRINE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdrenal incidentalomaen_US
dc.subjectExposureen_US
dc.subjectBisphenol-Aen_US
dc.subjectEndocrine disrupteren_US
dc.titleNonfunctional adrenal incidentalomas may be related to bisphenol-Aen_US
dc.typeArticle

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