Cytotoxin associated gene A-positive Helicobacter pylori strains in dyspeptic pregnant women
Yükleniyor...
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Sci Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The aim of the present study was to compare the Helicobacter pylori (HP) seropositivity and cytotoxin associated gene A (cagA) status in pregnant women with dyspeptic complaints and pregnant women with no gastrointestinal symptoms. Study design: Seventy-one consecutive pregnant women with gastrointestinal complaints and 72 age-matched pregnant women without any gastrointestinal symptoms or a history of gastrointestinal disease were included in the study. Demographic characteristics and H. pylori and cytotoxin associated gene A status of the groups were analysed. Results: The prevalence of H. pylori seropositivity was slightly but not significantly higher in patients with dyspeptic complaints compared to the controls (74.6% versus 63.8%, respectively, P > 0.05). The incidence of dyspeptic complaints were 53.5% in HP-seropositive and 40.9% in HP-seronegative women (P > 0.05). The prevalence of cytotoxin associated gene A positivity among H. pylori-seropositive women was significantly higher in dyspeptic pregnants compared to the controls (75.5% versus 45.7%, respectively, P = 0.002). Among HP-seropositive women, the incidence of dyspeptic complaints was significantly higher in cagA-positive patients compared to the cagA-negative ones (65.6% versus 34.2%, respectively, P = 0.002). When analysed according to the trimesters, the prevalence of cytotoxin associated gene A positivity among H. pylori-seropositive women was significantly higher in dyspeptic pregnants compared to the controls in the first trimester (68.0% versus 34.8%, respectively, P = 0.021). Conclusion: Cytotoxin associated gene A-positive, virulant H. pylori strains were found to be more frequently associated with dyspeptic complaints in pregnant women. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Yucel, Aykan/0000-0002-5888-692X
Anahtar Kelimeler
helicobacter pylori, cytotoxin associated gene A, dyspepsia, pregnancy
Kaynak
European Journal Of Obstetrics Gynecology And Reproductive Biology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
116
Sayı
2
Künye
closedAccess
