Cytotoxin associated gene A-positive Helicobacter pylori strains in dyspeptic pregnant women

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dc.contributor.authorNoyan, V.
dc.contributor.authorApan, T.Z.
dc.contributor.authorYücel, A.
dc.contributor.authorSağsöz, N.
dc.date.accessioned2020-06-25T17:40:03Z
dc.date.available2020-06-25T17:40:03Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.descriptionYucel, Aykan/0000-0002-5888-692X
dc.description.abstractObjective: The aim of the present study was to compare the Helicobacter pylori (HP) seropositivity and cytotoxin associated gene A (cagA) status in pregnant women with dyspeptic complaints and pregnant women with no gastrointestinal symptoms. Study design: Seventy-one consecutive pregnant women with gastrointestinal complaints and 72 age-matched pregnant women without any gastrointestinal symptoms or a history of gastrointestinal disease were included in the study. Demographic characteristics and H. pylori and cytotoxin associated gene A status of the groups were analysed. Results: The prevalence of H. pylori seropositivity was slightly but not significantly higher in patients with dyspeptic complaints compared to the controls (74.6% versus 63.8%, respectively, P > 0.05). The incidence of dyspeptic complaints were 53.5% in HP-seropositive and 40.9% in HP-seronegative women (P > 0.05). The prevalence of cytotoxin associated gene A positivity among H. pylori-seropositive women was significantly higher in dyspeptic pregnants compared to the controls (75.5% versus 45.7%, respectively, P = 0.002). Among HP-seropositive women, the incidence of dyspeptic complaints was significantly higher in cagA-positive patients compared to the cagA-negative ones (65.6% versus 34.2%, respectively, P = 0.002). When analysed according to the trimesters, the prevalence of cytotoxin associated gene A positivity among H. pylori-seropositive women was significantly higher in dyspeptic pregnants compared to the controls in the first trimester (68.0% versus 34.8%, respectively, P = 0.021). Conclusion: Cytotoxin associated gene A-positive, virulant H. pylori strains were found to be more frequently associated with dyspeptic complaints in pregnant women. (C) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ejogrb.2004.02.028
dc.identifier.endpage189en_US
dc.identifier.issn0301-2115
dc.identifier.issue2en_US
dc.identifier.pmid15358462
dc.identifier.scopus2-s2.0-4444301652
dc.identifier.scopusqualityQ2
dc.identifier.startpage186en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2004.02.028
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3225
dc.identifier.volume116en_US
dc.identifier.wosWOS:000224605600011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ireland Ltden_US
dc.relation.ispartofEuropean Journal Of Obstetrics Gynecology And Reproductive Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthelicobacter pylorien_US
dc.subjectcytotoxin associated gene Aen_US
dc.subjectdyspepsiaen_US
dc.subjectpregnancyen_US
dc.titleCytotoxin associated gene A-positive Helicobacter pylori strains in dyspeptic pregnant womenen_US
dc.typeArticle

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