Effectiveness of Dimethylsulfoxide on the Survival and Volume Preservation of Autologous Fat Graft Tissue: A Preliminary Study

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dc.contributor.authorSari, Elif
dc.contributor.authorBakar, Bulent
dc.contributor.authorSarkarati, Bahram
dc.contributor.authorBozdogan, Onder
dc.contributor.authorCavusoglu, Tarik
dc.date.accessioned2020-06-25T18:16:51Z
dc.date.available2020-06-25T18:16:51Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: The survival of autologous fat graft tissue is dependent on various factors, such as vascularization and inflammation. Objective: This study aims to evaluate the possible beneficial effects of dimethylsulfoxide (DMSO) on fat graft volume and survival. Methods: Eighteen male Wistar albino rats were divided randomly into three groups. An autologous fat graft obtained from the inguinal region of each rat was transferred to its back. DMSO was administered intraperitoneally (IP) in the DMSO-IP group and cutaneously (C) in the DMSO-C group once daily for 15 days after the surgical procedure. The control group underwent surgery but was not administered with DMSO. Two months after surgery, the grafted fatty tissues were harvested for histopathological and biochemical analyses. Results: The results showed that 2 months postoperatively, fat grafts of the DMSO-C and DMSO-IP groups weighed significantly more than the grafts of the control group. Moreover, the vascularity of the grafts was higher in the DMSO-C group than in the control group, and no significant difference was found between the two DMSO groups. The mean lipid peroxidation levels were the same in the three groups, but myeloperoxidation was significantly lower in the DMSO-C group than in the other two groups. Conclusions: The study results showed that cutaneous rather than intraperitoneal DMSO administration could preserve the quality and volume of transplanted fat tissue in rats by enhancing vascularity and decreasing inflammation.en_US
dc.identifier.citationElif Sari, MD and others, Effectiveness of Dimethylsulfoxide on the Survival and Volume Preservation of Autologous Fat Graft Tissue: A Preliminary Study, Aesthetic Surgery Journal, 36(2), 2016,NP58–NP67,en_US
dc.identifier.doi10.1093/asj/sjv119
dc.identifier.endpageNP67en_US
dc.identifier.issn1090-820X
dc.identifier.issn1527-330X
dc.identifier.issue2en_US
dc.identifier.pmid26242854
dc.identifier.scopus2-s2.0-84970021075
dc.identifier.scopusqualityQ1
dc.identifier.startpageNP58en_US
dc.identifier.urihttps://doi.org/10.1093/asj/sjv119
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6635
dc.identifier.volume36en_US
dc.identifier.wosWOS:000371692700003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofAesthetic Surgery Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffectiveness of Dimethylsulfoxide on the Survival and Volume Preservation of Autologous Fat Graft Tissue: A Preliminary Studyen_US
dc.typeArticle

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