Prophylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis

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dc.contributor.authorBezirci, Didem
dc.contributor.authorHendek, Meltem Karsiyaka
dc.contributor.authorOzcan, Gonen
dc.contributor.authorKul, Oguz
dc.contributor.authorAnteplioglu, Tugce
dc.contributor.authorOlgun, Ebru
dc.date.accessioned2025-01-21T16:34:13Z
dc.date.available2025-01-21T16:34:13Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose (6)-Shogaol is the most prevalent bioactive compound in ginger. The aim of this study was to examine both the prophylactic and therapeutic effects of (6)-shogaol in an experimental periodontitis model. Materials and Methods Thirty-five male Wistar albino rats were divided into four groups. In the healthy group (n=5), no intervention was undertaken. In the periodontitis group (n=10), periodontitis was induced by ligature placement for 14 days. In the prophylaxis group (n=10), periodontitis was induced with ligature placement for 14 days, and during this time, 20 mg/kg/day of (6)-shogaol was administered via oral gavage. In the therapeutic group (n=10), periodontitis was induced with ligature placement for 14 days, and following the removal of the ligature, 20 mg/kg/day of (6)-shogaol was administered via oral gavage for 14 days. Alveolar bone loss was histometrically measured, and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GP), nuclear factor kappa B (NF-kappa B), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were immunohistochemically analyzed. Results Alveolar bone loss was significantly lower in the healthy group than in the remaining groups, as well as in the therapeutic group than in the periodontitis group (p<0.001). RANKL/OPG was significantly higher in the periodontitis group compared to the remaining groups and in the prophylaxis group compared to the therapeutic group (p<0.001). MDA was significantly lower in the healthy group than in the remaining groups (p<0.001). SOD was significantly lower in the periodontitis group than in the prophylaxis and therapeutic groups (p=0.039 and p=0.042, respectively). GP was significantly lower in the healthy group than in the prophylaxis and therapeutic groups (p=0.031 and p=0.002, respectively). Conclusion The administration of (6)-shogaol modulated the RANKL/OPG balance and antioxidant status in rats with ligature-induced periodontitis.
dc.description.sponsorshipTUBIdot;TAK Starting R&D Projects Support Programme (3001); [217S332]
dc.description.sponsorshipThis study were supported by TUB & Idot;TAK Starting R&D Projects Support Programme (3001) (Project no: 217S332) .
dc.identifier.doi10.26650/eor.20241248958
dc.identifier.endpage43
dc.identifier.issn2630-6158
dc.identifier.issn2651-2823
dc.identifier.issue1
dc.identifier.pmid38481719
dc.identifier.scopus2-s2.0-85183675307
dc.identifier.scopusqualityQ3
dc.identifier.startpage37
dc.identifier.trdizinid1277220
dc.identifier.urihttps://doi.org/10.26650/eor.20241248958
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1277220
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23909
dc.identifier.volume58
dc.identifier.wosWOS:001214553500004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIstanbul Univ Press, Istanbul Univ Rectorate
dc.relation.ispartofEuropean Oral Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectExperimental periodontitis; ginger; oxidative stress; RANKL/OPG; shogaol
dc.titleProphylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis
dc.typeArticle

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