The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury

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dc.contributor.authorTuglu, Devrim
dc.contributor.authorYuvanc, Ercan
dc.contributor.authorYilmaz, Erdal
dc.contributor.authorGencay, Isin Yazici
dc.contributor.authorAtasoy, Pinar
dc.contributor.authorKisa, Ucler
dc.contributor.authorBatislam, Ertan
dc.date.accessioned2020-06-25T18:13:11Z
dc.date.available2020-06-25T18:13:11Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Batislam, Ertan/0000-0002-7493-4573
dc.description.abstractPURPOSE: To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats. METHODS: Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 mu g/kg Dex (group 3) and 100 mu g/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses. RESULTS: Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles: Dex 100 mu g/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 mu g/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations. CONCLUSION: The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides.en_US
dc.identifier.citationTuglu, D., Yuvanc, E., Yilmaz, E., Gencay, I. Y., Atasoy, P., Kisa, U., & Batislam, E. (2015). The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury. Acta cirurgica brasileira, 30(6), 414–421.en_US
dc.identifier.doi10.1590/S0102-865020150060000007
dc.identifier.endpage421en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue6en_US
dc.identifier.pmid26108030
dc.identifier.scopus2-s2.0-84933504668
dc.identifier.scopusqualityQ2
dc.identifier.startpage414en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020150060000007
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6147
dc.identifier.volume30en_US
dc.identifier.wosWOS:000356828100007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectSpermatic Cord Torsionen_US
dc.subjectAntioxidantsen_US
dc.subjectReperfusion Injuryen_US
dc.subjectTestisen_US
dc.subjectRatsen_US
dc.titleThe antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injuryen_US
dc.typeArticle

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