The Effects of High Dose Sugammadex on Rat Kidney Tissue Following Unilateral Ureteral Obstruction
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gazi Univ, Fac Med
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Unilateral ureteral obstruction (UUO) is commonly used model showed to imitate process of obstructive nephropathy in a feasible. The aim of this study is to evaluate the histopathological and biochemical effects of high doses sugammadex on kidney tissue of the rats those have early and late phase renal failure induced by UUO. Materials and Methods: Thirty male Wistar albino rats were randomly divided into five study groups. Control Group(C), UUO for 1 week Group(UUO-1), UUO-1 week treated with rocuronium and 96mg.kg(-1) Sugammadex Group(UUO-1 week-96S), UUO for 3 weeks Group(UUO-3) and UUO-3 weeks treated with rocuronium and 96mg.kg(-1 )Sugammadex Group(UUO-3 week-96S). The blood samples are stored at -20 degrees and MDA and NO were studied in the serum. Kidney tissue was removed for histopathological examination. Results: In the histopathological examination of all parameters (glomerular vacuolization(GV), tubular dilatation(TD), Vascular vacuolisation and hypertrophy(VVH), tubular cell degeneration and necrosis(TCDN), Bowman's space dilatation(BSD), tubular hyaline cylinders(THC), lymphocyte infiltration(LI), tubular cell sloughing(TCS), significant difference was observed for the kidney at the obstruction side. After 3 weeks, in the side of the all unobstructed groups' kidney tissues, significantly higher GV scores were detected compared with the GroupC. TD was observed more for the UUO1, UUO3 and UUO3S groups when compared with GroupC. And TCDN was observed more for the UUO1S and UUO3S groups when compared with GroupC. When the groups were compared with each other; it is observed that MDA and NO enzyme activities of UUO1S, UUO3 and UUO3S groups were significantly difference GroupC. Conclusion: High dose of sugammadex (96 mg.kg(-1)) can be used safely in UUO cases, on the other hand significant attention should be paid in bilateral ureteral obstruction cases. Our findings may be a guide for future animal and human studies investigating the effects of sugammadex on kidney tissue.
Açıklama
Arslan, Mustafa/0000-0003-4882-5063
Anahtar Kelimeler
Unilateral ureteral obstruction, sugammadex, MDA, NO, kidney histopathology, rat
Kaynak
Gazi Medical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
29
Sayı
4
Künye
Doğrul F., Bozkırlı F., Sezen Ş. C., Arpacı A. H., Boyunağa H., Arslan M., Ünal Y. (2018). The Effects of High Dose Sugammadex on Rat Kidney Tissue Following Unilateral Ureteral Obstruction. Gazi Medical Journal, 29(4), 280 - 286.
