The Effects of High Dose Sugammadex on Rat Kidney Tissue Following Unilateral Ureteral Obstruction

Basit Öğe Kaydı
dc.contributor.authorDogrul, Fikriye
dc.contributor.authorBozkirli, Fusun
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorArpaci, Hande
dc.contributor.authorBoyunaga, Hakan
dc.contributor.authorArslan, Mustafa
dc.contributor.authorUnal, Yusuf
dc.date.accessioned2020-06-25T18:29:55Z
dc.date.available2020-06-25T18:29:55Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractBackground: Unilateral ureteral obstruction (UUO) is commonly used model showed to imitate process of obstructive nephropathy in a feasible. The aim of this study is to evaluate the histopathological and biochemical effects of high doses sugammadex on kidney tissue of the rats those have early and late phase renal failure induced by UUO. Materials and Methods: Thirty male Wistar albino rats were randomly divided into five study groups. Control Group(C), UUO for 1 week Group(UUO-1), UUO-1 week treated with rocuronium and 96mg.kg(-1) Sugammadex Group(UUO-1 week-96S), UUO for 3 weeks Group(UUO-3) and UUO-3 weeks treated with rocuronium and 96mg.kg(-1 )Sugammadex Group(UUO-3 week-96S). The blood samples are stored at -20 degrees and MDA and NO were studied in the serum. Kidney tissue was removed for histopathological examination. Results: In the histopathological examination of all parameters (glomerular vacuolization(GV), tubular dilatation(TD), Vascular vacuolisation and hypertrophy(VVH), tubular cell degeneration and necrosis(TCDN), Bowman's space dilatation(BSD), tubular hyaline cylinders(THC), lymphocyte infiltration(LI), tubular cell sloughing(TCS), significant difference was observed for the kidney at the obstruction side. After 3 weeks, in the side of the all unobstructed groups' kidney tissues, significantly higher GV scores were detected compared with the GroupC. TD was observed more for the UUO1, UUO3 and UUO3S groups when compared with GroupC. And TCDN was observed more for the UUO1S and UUO3S groups when compared with GroupC. When the groups were compared with each other; it is observed that MDA and NO enzyme activities of UUO1S, UUO3 and UUO3S groups were significantly difference GroupC. Conclusion: High dose of sugammadex (96 mg.kg(-1)) can be used safely in UUO cases, on the other hand significant attention should be paid in bilateral ureteral obstruction cases. Our findings may be a guide for future animal and human studies investigating the effects of sugammadex on kidney tissue.en_US
dc.identifier.citationDoğrul F., Bozkırlı F., Sezen Ş. C., Arpacı A. H., Boyunağa H., Arslan M., Ünal Y. (2018). The Effects of High Dose Sugammadex on Rat Kidney Tissue Following Unilateral Ureteral Obstruction. Gazi Medical Journal, 29(4), 280 - 286.en_US
dc.identifier.doi10.12996/gmj.2018.78
dc.identifier.endpage286en_US
dc.identifier.issn2147-2092
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85054722553
dc.identifier.scopusqualityQ4
dc.identifier.startpage280en_US
dc.identifier.trdizinid294912
dc.identifier.urihttps://doi.org/10.12996/gmj.2018.78
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7501
dc.identifier.volume29en_US
dc.identifier.wosWOS:000445290000003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGazi Univ, Fac Meden_US
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUnilateral ureteral obstructionen_US
dc.subjectsugammadexen_US
dc.subjectMDAen_US
dc.subjectNOen_US
dc.subjectkidney histopathologyen_US
dc.subjectraten_US
dc.titleThe Effects of High Dose Sugammadex on Rat Kidney Tissue Following Unilateral Ureteral Obstructionen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
78e47d6a-7ac7-4046-84da-1a0be53b782c.pdf
Boyut:
2.58 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu