The role of cancer-related inflammation for prediction of poor survival in postmenopausal female patients with stage II/III colon cancer

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dc.contributor.authorZengin, Mehmet
dc.contributor.authorKarahan, Irfan
dc.date.accessioned2021-01-14T18:10:28Z
dc.date.available2021-01-14T18:10:28Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionkarahan, irfan/0000-0003-4669-1751
dc.description.abstractObjective: Cancer-related inflammation (CRI) is thought to be a successful predictor of prognosis in colon cancers (CC), but opinions on how to use it are highly variable. In this study, the role of CRI cells in survival for CC patients was investigated by considering gender and menopausal status. Methods: 163 stage II/III CC patients who underwent curative surgery between 1995 and 2015 were included in the study. The relationship between CRI cells was examined using a standard methodology. Results: High neutrophil-lymphocyte ratio (NLR) had a better relationship with prognostic factors, especially in postmenopausal women (gender, p = 0.037, positive surgical margin, p = 0.001; MSI, p < 0.001; Crohn's-like reaction, p = 0.001, etc). Also, the reproducibility of the study was better in postmenopausal women (intraobserver agreement = 0.72, intra-class correlation = 0.722, correlation of estimates = 0.718). In univariate analysis, 5-year survival was worse in postmenopausal women with high NLR (OS, p= 0.001; RFS, p < 0.001). In multivariate analysis, high NLR was independently a worse biomarker for OS (hazard ratio [HR], 1.29; 95% CI, 1.18-2.12; p = 0.001) and RFS (HR, 1.30; 95% CI, 1.21-2.59; p < 0.001) in postmenopausal women. Conclusions: NLR had an independent poor prognostic significance in postmenopausal female patients, and the use of a standard approach for methodology improved successful results.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1016/j.intimp.2020.106624
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid32492626
dc.identifier.scopus2-s2.0-85085642277
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2020.106624
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12625
dc.identifier.volume85en_US
dc.identifier.wosWOS:000548143500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherELSEVIERen_US
dc.relation.ispartofINTERNATIONAL IMMUNOPHARMACOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCancer-related inflammationen_US
dc.subjectNeutrophil-lymphocyte ratioen_US
dc.subjectGenderen_US
dc.subjectColon cancersen_US
dc.subjectStage II/IIen_US
dc.titleThe role of cancer-related inflammation for prediction of poor survival in postmenopausal female patients with stage II/III colon canceren_US
dc.typeArticle

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