Effects of Potentially Inappropriate Medications in Older Patients with Gastrointestinal System Cancer

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dc.contributor.authorÖzkan, Melike
dc.contributor.authorKarahan, İrfan
dc.contributor.authorYalçın, Selim
dc.contributor.authorŞengül Ayçiçek, Gözde
dc.date.accessioned2025-01-21T16:34:01Z
dc.date.available2025-01-21T16:34:01Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Potentially inappropriate medications (PIM) is a crucial problem in the geriatric population. The amount of prescription and unadherence increase because of the different problems encountered in cancer patients. Our aim was to evaluate the effects of PIM in patients with gastrointestinal system cancer and to investigate its relationship with chemotherapy side effects, mortality, and progression. Methods: This retrospective cohort study assessed 154 patients with gastrointestinal system cancer. Demographics and disease features, the presence of PIM according to the TIME-to-STOP criteria and baseline laboratory parameters were recorded. The effects of PIM on survival and adverse treatment events were evaluated. Results: 66.9% of the cases were male and 33.1% were female. The mean age was 71.9 +/- 6.4 years. The most common side effects of chemotherapy are nausea, vomiting, kidney injury, and pain. The most frequently used prescriptions among the 98 PIMs were gliclazide, hyoscine N-butylbromide, simethicone, diphenoxylate atropine, and thiocolchicoside. PIM was detected in 68.1% of the participants. Chemotherapy side effects were more common in PIM group (p<0.001, odds ratio =5.6). PIM had no effect on mortality. Factors associated with mortality were age, stage, albumin, creatinine, operation history, and progression. A significant relationship was found between age, cancer stage, albumin, creatinine, operation history, and PIM in the regression model. There was no relationship between PIM and progression-free survival. Conclusion: Chemotherapy toxicity may increase with PIM detected on diagnosis. We suggest that PIM is an important factor in predicting the side effects of chemotherapy and minimizing the adverse effects.
dc.identifier.doi10.4274/MMJ.galenos.2023.03063
dc.identifier.endpage290
dc.identifier.issn2149-2042
dc.identifier.issn2149-4606
dc.identifier.issue4
dc.identifier.pmid38148726
dc.identifier.scopus2-s2.0-85181482114
dc.identifier.scopusqualityQ2
dc.identifier.startpage284
dc.identifier.trdizinid1259299
dc.identifier.urihttps://doi.org/10.4274/MMJ.galenos.2023.03063
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1259299
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23894
dc.identifier.volume38
dc.identifier.wosWOS:001156674000007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofMedeniyet Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectPotentially inappropriate medications; mortality; gastrointestinal system cancers; chemotherapy; TIME-to-STOP criteria
dc.titleEffects of Potentially Inappropriate Medications in Older Patients with Gastrointestinal System Cancer
dc.title.alternativeGastrointestinal Sistem Kanseri Olan Yaşlı Hastalarda Potansiyel Olarak Uygun Olmayan İlaçların Etkileri
dc.typeArticle

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