High-resolution computed tomography findings in elderly patients with asthma

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dc.contributor.authorYilmaz, Sevda
dc.contributor.authorEkici, Aydanur
dc.contributor.authorEkici, Mehmet
dc.contributor.authorKeleş, Hatice
dc.date.accessioned2020-06-25T17:43:29Z
dc.date.available2020-06-25T17:43:29Z
dc.date.issued2006
dc.description.abstractObjective: Based on the hypothesis that airway remodelling is related to the duration of asthma, HRCT scanning should show greater abnormalities in the early-onset than the late-onset asthmatics. It was, therefore, intended to assess the presence and the frequency of airway and parenchymal abnormalities with high-resolution computed tomography (HRCT) in elderly asthmatic patients, and to determine whether these abnormalities are related to the duration of asthma. Patients and methods: Sixty-eight clinically stable asthmatic patients aged >= 60 yr were included in this prospective study. The patients were separated into two groups according to the duration of symptoms as late-onset asthma (n = 3 1) with disease duration of < 5 yr, and early-onset asthma (n = 37) with disease duration of >= 5 yr. All patients were lifelong non-smoker and had been using inhaled beta agonists and inhaled steroids. HRCT-scanning and histamine inhalation test were performed on all patients. Results: In comparison with late-onset asthmatic patients, those with early-onset asthma had significantly higher frequency of emphysema (21.6% versus 0.0%, p=0.006), bronchial dilatation (13.9% versus 0.0%, p=0.03) and bronchial wall thickness (41.7% versus 12.9%, p=0.01). Multiple logistic regression analysis identified that early-onset of disease was an independent risk factor for the presence of irreversible HRCT-scan abnormalities in elderly asthmatics [odds ratio (OR): 9.4 (2.7-32.7),p=0.00001]. Conclusion: Present data suggest that HRCT abnormalities in early-onset elderly asthmatics reflect parenchymal and airway changes that become irreversible throughout the long course of the disease. (c) 2006 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ejrad.2006.03.004
dc.identifier.endpage243en_US
dc.identifier.issn0720-048X
dc.identifier.issn1872-7727
dc.identifier.issue2en_US
dc.identifier.pmid16621393
dc.identifier.scopus2-s2.0-33746242235
dc.identifier.scopusqualityQ1
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org10.1016/j.ejrad.2006.03.004
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3737
dc.identifier.volume59en_US
dc.identifier.wosWOS:000239985000018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal Of Radiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectelderlyen_US
dc.subjectasthmaen_US
dc.subjectemphysemaen_US
dc.subjecthigh-resolution computed tomographyen_US
dc.titleHigh-resolution computed tomography findings in elderly patients with asthmaen_US
dc.typeArticle

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