Regulatory T-cell cytokines in patients with nonsegmental vitiligo

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dc.contributor.authorKidir, Mehtap
dc.contributor.authorKarabulut, Ayse A.
dc.contributor.authorErcin, Mustafa E.
dc.contributor.authorAtasoy, Pinar
dc.date.accessioned2020-06-25T18:23:03Z
dc.date.available2020-06-25T18:23:03Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn the etiopathogenesis of vitiligo, the role of suppressor cytokines, such as transforming growth factor- (TGF-) and interleukin-10 (IL-10), associated with regulatory T-cells (Treg) is not completely known. In this study, the role of Treg-cell functions in the skin of patients with nonsegmental vitiligo was investigated. Lesional and nonlesional skin samples from 30 adult volunteers ranging in age from 18 to 36 years with nonsegmental vitiligo were compared with normal skin area excision specimens of 30 benign melanocytic nevus cases as controls. All samples were evaluated staining for forkhead box P3 (Foxp3), TGF-, and IL-10 using the standardized streptavidin-biotin immunoperoxidase immunohistochemistry method. Foxp3 expression was lower in lesional vitiligo skin specimens compared to controls; it was also lower in lesional vitiligo specimens than nonlesional vitiligo specimens. IL-10 levels were lower in lesional vitiligo specimens compared to the controls, whereas IL-10 expression was significantly lower in lesional specimens compared with nonlesional specimens. TGF- expression was higher in both lesional and nonlesional skin specimens of patients with vitiligo compared to controls. TGF- expression was lower in lesional skin specimens than nonlesional skin specimens. In addition, there was no significant correlation between Foxp3 expression with TGF- and IL-10 expressions in lesional skin specimens in the vitiligo group. In this study, results supporting the contribution of Treg cells and IL-10 deficiency to the autoimmune process were obtained. Therefore, future studies are necessary to demonstrate the definitive role of Treg-cell functions in the etiopathogenesis of vitiligo.en_US
dc.description.sponsorshipKrkkale University Scientific Research Projects Coordination Unit [2010/22]en_US
dc.description.sponsorshipThis research was supported by the Krkkale University Scientific Research Projects Coordination Unit (project number: 2010/22).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/ijd.13564
dc.identifier.endpage588en_US
dc.identifier.issn0011-9059
dc.identifier.issn1365-4632
dc.identifier.issue5en_US
dc.identifier.pmid28247923
dc.identifier.scopus2-s2.0-85014005677
dc.identifier.scopusqualityQ1
dc.identifier.startpage581en_US
dc.identifier.urihttps://doi.org/10.1111/ijd.13564
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6995
dc.identifier.volume56en_US
dc.identifier.wosWOS:000398708500031
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleRegulatory T-cell cytokines in patients with nonsegmental vitiligoen_US
dc.typeArticle

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