The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction

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dc.contributor.authorKirdag, Mustafa Koray
dc.contributor.authorTuglu, Devrim
dc.contributor.authorYuvanc, Ercan
dc.contributor.authorKisa, Ucler
dc.contributor.authorBalci, Mahi
dc.contributor.authorBatislam, Ertan
dc.contributor.authorYilmaz, Erdal
dc.date.accessioned2020-06-25T18:30:26Z
dc.date.available2020-06-25T18:30:26Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: In this study, we aimed to investigate the antioxidant effects of selenium and coenzyme Q on renal damage in a partial unilateral ureteral obstruction (PUUO) in a rat model. Material and methods: A total of 24 Sprague-Dawley rats were divided into four groups as Group 1 Control Group, Group 2, PUUO Group, Group 3 PUUO + coenzyme Q group, Group 4 PUUO + selenium group. Paraoxonase (PON), total antioxidant capacity (TAC), and total oxidant levels (TOS) were analyzed biochemically from tissue and blood samples. Tissue samples were examined histopathologically. Results: The TAC in the tissues was found to be statistically significantly increased in Groups 3 and 4, compared to Group 2. Tissue TOS was found to be significantly reduced in Groups 3 and 4, compared to Group 2. Serum PON levels were significantly increased in Group 3 and 4, compared to Group 1 and 2. Histopathological examination showed that interstitial inflammation and congestion were lesser in the coenzyme Q and selenium groups than in the PUUO group. A more significant decrease was found in the selenium group than in the coenzyme Q group. Conclusion: Our study results showed that coenzyme Q and selenium reduced the oxidation and the damage in tissue in PUUO in rats.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.5152/tud.2018.22556
dc.identifier.endpage77en_US
dc.identifier.issn2149-3235
dc.identifier.issn2149-3057
dc.identifier.pmid30461382
dc.identifier.scopus2-s2.0-85077862943
dc.identifier.scopusqualityN/A
dc.identifier.startpage70en_US
dc.identifier.trdizinid537050
dc.identifier.urihttps://doi.org/10.5152/tud.2018.22556
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7644
dc.identifier.volume45en_US
dc.identifier.wosWOS:000502637300013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal Of Urology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoenzyme Qen_US
dc.subjectkidneyen_US
dc.subjectoxidative stress indexen_US
dc.subjectparaoxonaseen_US
dc.subjectpartial unilateral ureteral obstructionen_US
dc.subjectseleniumen_US
dc.subjecttotal antioxidant capacityen_US
dc.subjecttotal oxidant statusen_US
dc.titleThe effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstructionen_US
dc.typeArticle

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