Non-functioning adrenal incidentalomas may increase toxic metabolites

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dc.authoridCifci, Aydin/0000-0001-8449-2687
dc.contributor.authorKarahan, Irfan
dc.contributor.authorCeylan, Senay Durmaz
dc.contributor.authorGungunes, Askin
dc.contributor.authorCifci, Aydin
dc.contributor.authorEker, Fatih
dc.contributor.authorKisa, Ucler
dc.date.accessioned2025-01-21T16:42:53Z
dc.date.available2025-01-21T16:42:53Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground Non-functioning adrenal incidentaloma (NFAI) is a frequent diagnosis with increasing radiological tests. The emerging shreds of evidence showed that they might have negative cardiometabolic effects. The study aimed to investigate whether the toxic metabolites, asymmetric dimethylarginine (ADMA) levels, were altered in NFAI patients. Methods We included 43 NFAI patients and 41 controls with similar ages and body mass indices in the study. We compared plasma ADMA levels of both groups and noted the radiological features of NFAIs. Results The ADMA levels were significantly higher in NFAI patients than in the control group (307.04 ng/ml, range 81.89-577.7 ng/ml vs 192.54 ng/ml, range 70.61-440.26 ng/ml, p = 0.001). Nevertheless, we could not reach a significant correlation between ADMA levels and mass size. Conclusion The ADMA is known as a toxin and is increased in NFAI patients. NFAIs may not be innocent and may be considered a potential risk for the body. Further investigations were needed for more explanations.
dc.identifier.doi10.1007/s00508-021-01909-9
dc.identifier.endpage129
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.issue3-4
dc.identifier.pmid34255169
dc.identifier.scopus2-s2.0-85109970355
dc.identifier.scopusqualityQ1
dc.identifier.startpage125
dc.identifier.urihttps://doi.org/10.1007/s00508-021-01909-9
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25163
dc.identifier.volume134
dc.identifier.wosWOS:000673221000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectNon-functioning adrenal incidentaloma; Asymmetric dimethylarginine; Toxicity; Dimethylarginine; Uremic toxin
dc.titleNon-functioning adrenal incidentalomas may increase toxic metabolites
dc.typeArticle

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