Effects of exposure to new inhalational anesthetics on spermatogenesis and sperm morphology in rabbits
Loading...
Date
2005
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Inc
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
The effects of chronic exposure to new inhalation anesthetics (sevoflurane and isoflurane) on spermatogenesis and sperm morphology were examined in 23 rabbits, randomly divided in 3 groups. Rabbits received 20 exposure hours (four hours/day x 5 days), as follows: group I: 2.3% (1.2 MAC) sevoflurane+2L/min oxygen, group II: 1.3% (1.2 MAC) isoflurane+2L/min oxygen, and group III (control): 2L/min oxygen. Semen was collected on the 12th, 19th, 26th, 33rd, and 41st days of exposure. Sperm concentration, motility and morphological changes were evaluated. On the 41st day, testicular biopsies were taken and observed with light microscopy. Sperm concentration and motility significantly decreased in the sevoflurane and the isoflurane groups, compared to control. There were no significant changes in the control group. It is concluded that chronic exposure to the new inhalational anesthetics had negative effects on spermatogenesis and sperm morphology.
Description
CINCIK, Mehmet/0000-0002-0717-1756
Keywords
concentration, inhalational anesthetics, isoflurane, motility, sevoflurane, sperm, spermatogenesis, testis
Journal or Series
Archives Of Andrology
WoS Q Value
Q4
Scopus Q Value
N/A
Volume
51
Issue
4
Citation
closedAccess
