Fungal growth inside saline-filled implants and the role of injection ports in fungal translocation: In vitro study

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dc.contributor.authorSaray, A
dc.contributor.authorKilic, D
dc.contributor.authorKaygusuz, S
dc.contributor.authorBoyunaga, H
dc.contributor.authorOzluk, O
dc.date.accessioned2020-06-25T17:40:03Z
dc.date.available2020-06-25T17:40:03Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.description.abstractInfection is a serious complication of breast. augmentation and tissue expansion with inflatable devices. Several reports have shown that fungi may be able to survive, colonize, and even cause infection in saline-filled devices. The mechanism of how them, penetrate, spread, and colonize inside the inflatable implants is not exactly understood. The authors assessed both the expander membrane and the port in terms of leakage and penetration of Candida albicans and Aspergillus niger in an in vitro model. Thirty saline-filled expanders connected to the injection port were placed in sterile containers filled with tryptic soy broth culture medium to simulate the clinical situation in phases I and II. Intactand multipunctured ports were used in the first and second phases of the study, respectivelv. Either the container or the implant was inoculated with one of these fungi, and six implants in containers without fungal inoculation served as controls. As a third phase, intraluminal survival of fungi was investigated in saline-filled containers (n = 12) in 21 clays. The silicone membrane, with its intact connecting tube and port, was impermeable to these fungi, whereas both fungi were able to diffuse inside-out or outside-in through the punctured ports. C. albicans did not Survive beyond 18 days in saline, whereas A. niger continued to multiply at day 21. Chemical analyses of the implant fluids revealed that the contents of the culture medium diffused into the implants in phases I and II. The data show that an intact. silicone membrane is impermeable to fungi, and punctured ports allow translocation of fungi into the implants. Fungi can grow and reproduce in a saline-only environment, and their survival periods differ among the species. Furthermore, their Survival maybe enhanced by the influx of substances through the implant shell.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/101.prs.0000135855.29657.91
dc.identifier.endpage1178en_US
dc.identifier.issn0032-1052
dc.identifier.issue5en_US
dc.identifier.pmid15457030
dc.identifier.scopus2-s2.0-14944342171
dc.identifier.scopusqualityQ1
dc.identifier.startpage1170en_US
dc.identifier.urihttps://doi.org/10.1097/101.prs.0000135855.29657.91
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3235
dc.identifier.volume114en_US
dc.identifier.wosWOS:000224396700022
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPlastic And Reconstructive Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleFungal growth inside saline-filled implants and the role of injection ports in fungal translocation: In vitro studyen_US
dc.typeArticle

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