Potential Drug-Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Study
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Int Scientific Information, Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Improper use of antimicrobials can cause adverse drug events and high costs. The purpose of this study was to investigate the frequency and potential drug-drug interactions associated with antimicrobials among hospitalized patients. Material/Methods: This study was conducted on the same day in 5 different hospitals in Turkey. We included patients aged (3) 18 years who received at least 1 antimicrobial drug and at least 1 of any other drug. The Micromedex (R) online drug reference system was used to control and describe the interactions. Drug interactions were classified as contraindicated, major, moderate, and minor. Results: Potential drug-drug interactions with antimicrobials were 26.4% of all interactions. Five (42%) of 12 contraindicated interactions and 61 (38%) of 159 major interactions were with antimicrobials. Quinolones, triazoles, metronidazole, linezolid, and clarithromycin accounted for 173 (25.7%) of 673 prescribed antimicrobials, but were responsible for 141 (92.1%) of 153 interactions. In multivariate analysis, number of prescribed antimicrobials (odds ratio: 2.3001, 95% CI: 1.6237-3.2582), number of prescribed drugs (odds ratio: 1.2008, 95% CI: 1.0943-1.3177), and hospitalization in the university hospital (odds ratio: 1.7798, 95% CI: 1.0035-3.1564) were independent risk factors for developing drug interactions. Conclusions: Due to risk of drug interactions, physicians should be more cautious when prescribing antimicrobials, particularly when prescribing quinolones, linezolid, azoles, metronidazole, and macrolides.
Açıklama
Ulu, Aslihan Candevir/0000-0001-9340-516X; Inal, Ayse Seza/0000-0002-1182-7164
Anahtar Kelimeler
Anti-Infective Agents, Drug Interactions, Polypharmacy
Kaynak
Medical Science Monitor
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
24
Sayı
Künye
Kuscu, F., Ulu, A., Inal, A. S., Suntur, B. M., Aydemir, H., Gul, S., Ecemis, K., Komur, S., Kurtaran, B., Ozkan Kuscu, O., & Tasova, Y. (2018). Potential Drug-Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Study. Medical science monitor : international medical journal of experimental and clinical research, 24, 4240–4247.
