Potential Drug-Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Study

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dc.contributor.authorKuscu, Ferit
dc.contributor.authorUlu, Astihan
dc.contributor.authorInal, Ayse S.
dc.contributor.authorSuntur, Bedia M.
dc.contributor.authorAydemir, Hande
dc.contributor.authorGul, Serdar
dc.contributor.authorTasova, Yesim
dc.date.accessioned2020-06-25T18:29:34Z
dc.date.available2020-06-25T18:29:34Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionUlu, Aslihan Candevir/0000-0001-9340-516X; Inal, Ayse Seza/0000-0002-1182-7164
dc.description.abstractBackground: Improper use of antimicrobials can cause adverse drug events and high costs. The purpose of this study was to investigate the frequency and potential drug-drug interactions associated with antimicrobials among hospitalized patients. Material/Methods: This study was conducted on the same day in 5 different hospitals in Turkey. We included patients aged (3) 18 years who received at least 1 antimicrobial drug and at least 1 of any other drug. The Micromedex (R) online drug reference system was used to control and describe the interactions. Drug interactions were classified as contraindicated, major, moderate, and minor. Results: Potential drug-drug interactions with antimicrobials were 26.4% of all interactions. Five (42%) of 12 contraindicated interactions and 61 (38%) of 159 major interactions were with antimicrobials. Quinolones, triazoles, metronidazole, linezolid, and clarithromycin accounted for 173 (25.7%) of 673 prescribed antimicrobials, but were responsible for 141 (92.1%) of 153 interactions. In multivariate analysis, number of prescribed antimicrobials (odds ratio: 2.3001, 95% CI: 1.6237-3.2582), number of prescribed drugs (odds ratio: 1.2008, 95% CI: 1.0943-1.3177), and hospitalization in the university hospital (odds ratio: 1.7798, 95% CI: 1.0035-3.1564) were independent risk factors for developing drug interactions. Conclusions: Due to risk of drug interactions, physicians should be more cautious when prescribing antimicrobials, particularly when prescribing quinolones, linezolid, azoles, metronidazole, and macrolides.en_US
dc.identifier.citationKuscu, F., Ulu, A., Inal, A. S., Suntur, B. M., Aydemir, H., Gul, S., Ecemis, K., Komur, S., Kurtaran, B., Ozkan Kuscu, O., & Tasova, Y. (2018). Potential Drug-Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Study. Medical science monitor : international medical journal of experimental and clinical research, 24, 4240–4247.en_US
dc.identifier.doi10.12659/MSM.908589
dc.identifier.endpage4247en_US
dc.identifier.issn1643-3750
dc.identifier.pmid29924770
dc.identifier.scopus2-s2.0-85049689447
dc.identifier.scopusqualityQ1
dc.identifier.startpage4240en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.908589
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7376
dc.identifier.volume24en_US
dc.identifier.wosWOS:000436365200003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-Infective Agentsen_US
dc.subjectDrug Interactionsen_US
dc.subjectPolypharmacyen_US
dc.titlePotential Drug-Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Studyen_US
dc.typeArticle

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