The potential role of human HIV-1 TAT-Interactive Protein 2 levels in the pathogenesis of contact dermatitis

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dc.authoridBilen, Handan/0000-0001-6507-1406
dc.authoridMetin, Mahmut Sami/0000-0002-5099-8521
dc.contributor.authorMetin, Mahmut Sami
dc.contributor.authorBilen, Handan
dc.contributor.authorElmas, Ömer Faruk
dc.contributor.authorAkdeniz, Necmettin
dc.date.accessioned2025-01-21T16:34:25Z
dc.date.available2025-01-21T16:34:25Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: Human HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is a gene that is extensively expressed in human tissues as well as in tumor tissues. This study aimed to explore the potential role of HTATIP2/TIP30 in contact dermatitis (CD), which is one of the most common inflammatory cutaneous conditions. Materials and methods: This cross-sectional study involved adult patients with acute contact dermatitis who were admitted to the outpatient dermatology clinic of a tertiary hospital and healthy adult volunteers without any cutaneous or systemic diseases. The blood concentration of HTATIP2/TIP30 was measured using ELISA kits. Results: The research sample consisted of 31 patients with CD (18 males, 13 females) and 20 healthy control subjects (14 males, 6 females). The mean ages of the patients with CD and healthy volunteers were 37 and 30 years, respectively (p > 0.05). The mean value of serum HTATIP2/TIP30 levels in patients with CD was 1.65 ng ml-1, which is 0.60 ng ml-1 in the control group (p = 0.02) Conclusion: In this study, serum levels of HTATIP2/TIP30 were statistically significantly higher in patients with CD when compared to healthy controls. This outcome may indicate possible role of HTATIP2/TIP30 in the pathogenesis of CD.
dc.identifier.doi10.3906/sag-2106-81
dc.identifier.endpage3021
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6
dc.identifier.pmid34688245
dc.identifier.scopus2-s2.0-85123025195
dc.identifier.scopusqualityQ1
dc.identifier.startpage3017
dc.identifier.trdizinid477703
dc.identifier.urihttps://doi.org/10.3906/sag-2106-81
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay477703
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23963
dc.identifier.volume51
dc.identifier.wosWOS:000731456300026
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectContact dermatitis; CC3; TIP30; HTATIP2; TIP30
dc.titleThe potential role of human HIV-1 TAT-Interactive Protein 2 levels in the pathogenesis of contact dermatitis
dc.typeArticle

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