BCL-2-related apoptosis markers in cutaneous human papillomavirus-associated lesions

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dc.contributor.authorErkek, E
dc.contributor.authorBozdogan, O
dc.contributor.authorAtasoy, P
dc.contributor.authorBirol, A
dc.contributor.authorKocak, M
dc.date.accessioned2020-06-25T17:40:09Z
dc.date.available2020-06-25T17:40:09Z
dc.date.issued2004
dc.departmentKırıkkale Üniversitesi
dc.descriptionOzturk Durmaz, Emel/0000-0003-0661-9720
dc.description.abstractBackground: Human papilloma virus (HPV) is an etiological agent in benign and malignant epithelial tumors. Resistance to apoptotic stimuli by viral strategies represents an immunologic escape mechanism during virus-induced tumor development and is critical for efficient replication of the virus. Objective: The aim of the present study was to investigate a role of bcl-family proteins in the anti-apoptotic pathways modulated by low-risk HPVs in the development of benign HPV-associated cutaneous tumors. Methods: Forty lesional biopsy specimens from HPV-associated cutaneous lesions and 11 non-lesional control skin biopsies were studied by immunohistochemical analysis for the differential expressions of HPV antigens, the pro-apoptotic bax protein, and the antiapoptotic bcl-2 and bcl-x proteins. Results: Compared with the normal epidermis, bcl-2 and bcl-x expression were significantly reduced in the lesional epidermis. Bax was expressed in HPV-associated cutaneous lesions, although the expression did not reveal a significant deviation from that in normal skin. Conclusion: These findings indicate a discordant expression of bcl2/ bcl-x and bax proteins in HPV-associated skin lesions and suggest that low-risk HPVs mediate other pathways that bypass the action of anti-apoptotic bcl-2 and bcl-x proteins. The presence of bax expression with a prominent decrease in bcl-2/ bax ratio and the lack of massive apoptosis in HPV-associated benign epithelial lesions may imply that interference with the pro-apoptotic proteins of bcl-family may constitute one of the several mechanisms mediated by HPV oncoproteins for the suppression of apoptotic process.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1097/00000372-200404000-00005
dc.identifier.endpage118en_US
dc.identifier.issn0193-1091
dc.identifier.issue2en_US
dc.identifier.pmid15024192
dc.identifier.scopus2-s2.0-1842562405
dc.identifier.scopusqualityQ3
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1097/00000372-200404000-00005
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3309
dc.identifier.volume26en_US
dc.identifier.wosWOS:000222430600005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal Of Dermatopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectbaxen_US
dc.subjectbcl-2en_US
dc.subjectbcl-xen_US
dc.subjecthuman papillomavirusen_US
dc.subjectwartsen_US
dc.titleBCL-2-related apoptosis markers in cutaneous human papillomavirus-associated lesionsen_US
dc.typeArticle

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