Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride

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dc.contributor.authorAtmaca, Nurgul
dc.contributor.authorYildirim, Ebru
dc.contributor.authorGuner, Bayram
dc.contributor.authorKabakci, Ruhi
dc.contributor.authorBilmen, Fatih Sultan
dc.date.accessioned2020-06-25T18:12:27Z
dc.date.available2020-06-25T18:12:27Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionKABAKCI, Ruhi/0000-0001-9131-0933
dc.description.abstractWe investigated the protective effects of resveratrol on hematological and biochemical changes induced by fluoride in rats. A total of 28 rats were divided into 4 groups: control, resveratrol, fluoride, and fluoride/resveratrol (n = 7 each), for a total of 21 days of treatment. Blood samples were taken and hematological and biochemical parameters were measured. Compared to the control group, the fluoride-treated group showed significant differences in several hematological parameters, including decreases in WBC, RBC, and PLT counts and neutrophil ratio. The group that received resveratrol alone showed a decrease in WBC count compared to the control group. Furthermore, in comparison to the control group, the fluoride group showed significantly increased ALT enzyme activity and decreased inorganic phosphorus level. The hematological and biochemical parameters in the fluoride + resveratrol treated group were similar to control group. In the fluoride + resveratrol group, resveratrol restored the changes observed following fluoride treatment, including decreased counts of WBC, RBC, and PLT, decreased neutrophil ratio and inorganic phosphorus levels, and elevated ALT enzyme activity. The present study showed that fluoride caused adverse effects in rats and that resveratrol reduced hematological and biochemical alterations produced by fluoride exposure.en_US
dc.identifier.citationNurgül Atmaca, Ebru Yıldırım, Bayram Güner, Ruhi Kabakçı, Fatih Sultan Bilmen, "Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride", BioMed Research International, vol. 2014, Article ID 698628, 5 pages, 2014.en_US
dc.identifier.doi10.1155/2014/698628
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid24995323
dc.identifier.scopus2-s2.0-84903592111
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2014/698628
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5924
dc.identifier.wosWOS:000337492600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofBiomed Research International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluorideen_US
dc.typeArticle

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