Effects of Intracisternal Dexmedetomidine on Cerebral Neuronal Cells in Rat: A Preliminary Study

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dc.contributor.authorKose, Emine Arzu
dc.contributor.authorBakar, Bulent
dc.contributor.authorKasimcan, Omur
dc.contributor.authorAtilla, Pergin
dc.contributor.authorKilinc, Kamer
dc.contributor.authorMuftuoglu, Sevda
dc.contributor.authorApan, Alpaslan
dc.date.accessioned2020-06-25T18:07:32Z
dc.date.available2020-06-25T18:07:32Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionATILLA, PERGIN/0000-0001-5132-0002
dc.description.abstractAIM:The aim was to investigate whether dexmedetomidine had a toxic effect on cerebral neurons when it was administered centrally into the cerebrospinal fluid by the intracisternal route. MATERIAL and METHODS: Eighteen rats were anesthetized and the right femoral artery was cannulated. Mean arterial pressures, heart rates, arterial carbon dioxide tension, arterial oxygen tension, and blood pH were recorded. When the free cerebrospinal fluid flow was seen, 0.1 ml normal saline (Group SIC, n=6) or 9 mu g/kg diluted dexmedetomidine in 0.1 ml volume (Group DIC, n=6) was administered into the cisterna magna of rats. After 24 hours, the whole body blood was collected for measurement of plasma lipid peroxidation (LPO) levels. The hippocampal formations used for histopathological examination and measurement of tissue LPO levels. RESULTS: There was a statistically significant difference between the DIC/SIC groups and DIC/CONTROL groups regarding the brain LPO levels (p=0.002, p<0.001, respectively). Plasma LPO levels were statistically different between the CONTROL/DIC groups, CONTROL/SIC groups, DIC/ SIC groups (p=0.002, p=0.047, p=0.025, respectively),The picnotic neuron counts were different between the CONTROL/SIC groups, CONTROL/ DIC groups, DIC/SIC groups (p<0.001, p=0.001, p=0.024, respectively). CONCLUSION: In conclusion, dexmedetomidine had a toxic effect on cerebral neurons when it was administered centrally into the cerebrospinal fluid by the intracisternal route.en_US
dc.identifier.citationKöse E. A., Bakar B., Kasımcan Ö., Atilla P., Kılınç K., Müftüoğlu S., Apan A. (2013). Effects of intracisternal dexmedetomidine on cerebral neuronal cells in rat: A preliminary study. Turkish Neurosurgery, 23(1), 38 - 44.en_US
dc.identifier.doi10.5137/1019-5149.JTN.6261-12.2
dc.identifier.endpage44en_US
dc.identifier.issn1019-5149
dc.identifier.issue1en_US
dc.identifier.pmid23344865
dc.identifier.scopus2-s2.0-84874877522
dc.identifier.scopusqualityQ3
dc.identifier.startpage38en_US
dc.identifier.trdizinid150878
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.6261-12.2
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5602
dc.identifier.volume23en_US
dc.identifier.wosWOS:000334560700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectIntracisternalen_US
dc.subjectIntrathecalen_US
dc.subjectHippocampusen_US
dc.subjectBrainen_US
dc.subjectCerebral neuronen_US
dc.titleEffects of Intracisternal Dexmedetomidine on Cerebral Neuronal Cells in Rat: A Preliminary Studyen_US
dc.typeArticle

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