The effect of low-dose methotrexate on autologous fat graft survival

Basit Öğe Kaydı
dc.contributor.authorSari, Elif
dc.contributor.authorBakar, Bulent
dc.contributor.authorSarkarati, Bahram
dc.contributor.authorBozdogan, Onder
dc.contributor.authorCavusoglu, Tarik
dc.date.accessioned2020-06-25T18:22:27Z
dc.date.available2020-06-25T18:22:27Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: The survival of autologous fat graft tissue is dependent on various factors such as vascularization and inflammation. The aim of the present study was to evaluate the possible beneficial effects of low-dose methotrexate (LD-MTX) on fat graft volume and survival. Materials and methods: A total of 13 male Wistar albino rats were divided into two groups, a control group and an LD-MTX group. An autologous fat graft obtained from the inguinal region of each rat was transferred to its back. LD-MTX was administered intraperitoneally in the LD-MTX group once a week for 4 weeks after the surgical procedure. The control group underwent surgery but was not administered MTX. Fat grafts were harvested for analyses. Results: The results showed that 2 months postoperatively the fat graft weights of the control and LD-MTX groups were not significantly different. In addition, the vascularity of the grafts was higher in the LD-MTX group than it was in the control group. The mean lipid peroxidation levels were essentially the same in the two groups, but myeloperoxidation was significantly lower in the LD-MTX group than it was in the other group. Conclusion: The results showed that LD-MTX administration may not preserve the quality and volume of transplanted fat tissue in rats.en_US
dc.identifier.citationSarı E., Bakar B., Sarkaratı B., Bozdoğan Ö., Çavuşoğlu T. (2016). The effect of low-dose methotrexate on autologous fat graft survival. Turkish Journal of Medical Sciences, 46(4), 1215 - 1222.en_US
dc.identifier.doi10.3906/sag-1503-7
dc.identifier.endpage1222en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid27513428
dc.identifier.scopus2-s2.0-84975853292
dc.identifier.scopusqualityQ1
dc.identifier.startpage1215en_US
dc.identifier.trdizinid249648
dc.identifier.urihttps://doi.org/10.3906/sag-1503-7
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6729
dc.identifier.volume46en_US
dc.identifier.wosWOS:000378646700041
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFat graften_US
dc.subjectfat graft survivalen_US
dc.subjectmethotrexateen_US
dc.titleThe effect of low-dose methotrexate on autologous fat graft survivalen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
Ä°sim:
f4c5a268-da80-49e9-9b64-58837e56da31.pdf
Boyut:
2.23 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
Ä°ndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu