Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury

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dc.contributor.authorOzer, Abdullah
dc.contributor.authorDemirtas, Huseyin
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorErer, Dilek
dc.contributor.authorKilic, Yigit
dc.contributor.authorMardin, Baris
dc.contributor.authorOktar, G. Levent
dc.date.accessioned2020-06-25T18:30:11Z
dc.date.available2020-06-25T18:30:11Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractBackground/aim: The protective effect of erdosteine on local and distant organ injury due to ischemia/reperfusion has been well documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of erdosteine on erythrocyte deformability in the infrarenal aorta of rats undergoing ischemia/reperfusion. Materials and methods: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups: a randomized control group (group 'control', n = 6), an ischemia/reperfusion group without erdosteine (group 'ischemia/reperfusion', n = 6), and an ischemia/reperfusion group with erdosteine at 150 mg kg(-1), intraperitoneally (group 'ischemia/reperfusion - erdosteine', n = 6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were conducted. Results: Comparisons of the control and ischemia/reperfusion - erdosteine groups revealed similar results (P = 0.051). The values of the ischemia/reperfusion group were significantly higher than those of the control and ischemia/reperfusion - erdosteine groups (P < 0.0001 and P = 0.024, respectively). Relative resistance, a marker of erythrocyte deformability, was increased significantly by ischemia/reperfusion compared to the control and ischemia/reperfusion - erdosteine groups (P < 0.05). Conclusion: We detected unfavorable effects of ischemia/reperfusion on erythrocyte deformability, which may lead to disturbance in blood flow and hence tissue perfusion in the infrarenal rat aorta. We also found that erdosteine had beneficial effects by reversing undesirable effects of ischemia/reperfusion. However, these promising results should be further supported by more detailed studies with larger volumes.en_US
dc.identifier.citationÖzer A., Demirtaş H., Çomu F. M., Erer D., Kılıç Y., Mardin B., Arslan M., Küçük A., Oktar G. L. (2018). Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury. Turkish Journal of Medical Sciences, 48(1), 187 - 190.en_US
dc.identifier.doi10.3906/sag-1706-160
dc.identifier.endpage190en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid29479982
dc.identifier.scopus2-s2.0-85042485345
dc.identifier.scopusqualityQ1
dc.identifier.startpage187en_US
dc.identifier.trdizinid299165
dc.identifier.urihttps://doi.org/10.3906/sag-1706-160
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7582
dc.identifier.volume48en_US
dc.identifier.wosWOS:000425902900030
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectErythrocyte deformabilityen_US
dc.subjectischemia reperfusion injuryen_US
dc.subjecterdosteineen_US
dc.subjectlower limben_US
dc.titleProtective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injuryen_US
dc.typeArticle

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