Effects of functional poly(ethylene terephthalate) nanofibers modified with sericin-capped silver nanoparticles on histopathological changes in parenchymal organs and oxidative stress in a rat burn wound model

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dc.authoridŞahin, Yaşar/0000-0001-5936-4210
dc.contributor.authorŞahin, Yaşar
dc.contributor.authorGün Gök, Zehra
dc.contributor.authorAlçığır, Mehmet Eray
dc.contributor.authorÇınar, Miyas
dc.date.accessioned2025-01-21T16:33:38Z
dc.date.available2025-01-21T16:33:38Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, it was aimed to investigate the effect of a poly(ethylene terephthalate)-g-poly(hydroxyethyl methacrylate) (PET-g-HEMA) nanofiber wound dressing modified with sericin-coated silver nanoparticles (S-AgNPs) on internal organs, oxidative stress, and biochemical parameters. To establish a burn model, the backs of anesthetized rats were shaved and then third-degree burns were created with a round-bottomed stainless steel rod 2 cm in diameter kept in 100 degrees C water for 20 seconds. The wounds of the negative control group (G1) were covered with standard bandages; the wounds of the positive control group (G2) were covered with silvercel, used as burn wound material; and the wounds of the experimental group (G3) were covered with PET-based dressing material. Histopathological changes in organs (liver, kidneys, heart, pancreas, lungs), total oxidant status (TOS), total antioxidant status (TAS), nitric oxide (NO), and biochemical parameters (serum aspartate aminotransferase [AST], alanine aminotransferase [ALT], gamma glutamyl transpeptidase [GGT], creatine kinase, lactate dehydrogenase [LDH], total protein, albumin, globulin, urea) were examined. Compared with the G1 group, plasma AST, ALT, and GGT levels were found to be significantly decreased in G2 and G3 (P<0.001). Plasma TAS was found to be significantly increased in G2 and G3 compared to G1 (P<0.05). Compared to the G1 group, degenerative and necrotic changes in the liver, kidneys, and pancreas were found to be significantly reduced in G2 and G3 (P<0.05). In conclusion, this work demonstrates that the synthesized PET-based wound dressing material has the capacity to be used commercially.
dc.identifier.doi10.33988/auvfd.990270
dc.identifier.endpage140
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85145270954
dc.identifier.scopusqualityQ3
dc.identifier.startpage131
dc.identifier.trdizinid1177891
dc.identifier.urihttps://doi.org/10.33988/auvfd.990270
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1177891
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23820
dc.identifier.volume70
dc.identifier.wosWOS:000957950300004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectHistopathological analysis; Oxidative stress; PET; Silver nanoparticles; Wound dressing
dc.titleEffects of functional poly(ethylene terephthalate) nanofibers modified with sericin-capped silver nanoparticles on histopathological changes in parenchymal organs and oxidative stress in a rat burn wound model
dc.typeArticle

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