Radioprotective effect of lycopene on chromosomal aberrations (CAs) induced by gamma radiation in human lymphocytes

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dc.contributor.authorÇavuşoğlu, Kültiğin
dc.contributor.authorYalçın, Emine
dc.date.accessioned2020-06-25T17:48:53Z
dc.date.available2020-06-25T17:48:53Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe present study was carried out to evaluate the radioprotective role of lycopene on chromosomal aberrations (CAs) induced by gamma (gamma) radiation in human lymphocytes. For this purpose, we used in vitro dose-effect relationship, and correlate these data with statistical parameters. CAs were evaluated in terms of chromosome break, dicentric, tricentric, acentric, fragment and ring. Mitotic index (MI) and aberrant metaphase number (AMN) were also calculated. Nine groups of lymphocyte culture were prepared: (I) Control group did not received radiation or lycopene, (II) positive control; lymphocytes were treated only with 0.020 mu M lycopene, (III) radiation group; lymphocytes were treated with only 10 Gy gamma-radiation, (IV) lymphocytes were treated with 0.001, mu M lycopene before irradiation, (V) lymphocytes were treated with 0.005 mu M lycopene before irradiation, (VI) lymphocytes were treated with 0.010 mu M lycopene before irradiation, (VII) lymphocytes were treated with 0.015 mu M lycopene before irradiation, (VIII) lymphocytes were treated with 0.018 mu M lycopene before irradiation, (IX) lymphocytes were treated with treated with 0.020 mu M lycopene before irradiation. The results indicated that all lycopene-supplemented lymphocytes showed a lower CAs frequency than lymphocytes in only radiation treated group. It was seen that lycopene had a protective effect on CAs particularly at 0.010, 0.015 and 0.018 mu M concentrations, but this effect saturated at 0.020 mu M concentration. Besides, MI increased and AMN decreased depending on applied lycopene doses. In vitro results showed that the lycopene supplementation decreases frequency of CAs and its protective role against chromosome damages induced by radiation is dose-dependent until a certain stage.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage117en_US
dc.identifier.issn0254-8704
dc.identifier.issue1en_US
dc.identifier.pmid20112872
dc.identifier.scopus2-s2.0-59349117122
dc.identifier.scopusqualityQ3
dc.identifier.startpage113en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4584
dc.identifier.volume30en_US
dc.identifier.wosWOS:000262706900018
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTriveni Enterprisesen_US
dc.relation.ispartofJournal Of Environmental Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAberrant metaphase numberen_US
dc.subjectChromosomal aberrationsen_US
dc.subjectGamma radiationen_US
dc.subjectLycopeneen_US
dc.subjectMitotic indexen_US
dc.titleRadioprotective effect of lycopene on chromosomal aberrations (CAs) induced by gamma radiation in human lymphocytesen_US
dc.typeArticle

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