PCR investigation of Panton-Valentine leukocidin, enterotoxin, exfoliative toxin, and agr genes in Staphylococcus aureus strains isolated from psoriasis patients

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dc.contributor.authorGocmen, Julide Sedef
dc.contributor.authorSahiner, Neriman
dc.contributor.authorKocak, Mukadder
dc.contributor.authorKarahan, Zeynep Ceren
dc.date.accessioned2020-06-25T18:15:47Z
dc.date.available2020-06-25T18:15:47Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: Staphylococcus aureus colonization is a determiner of disease activation in psoriasis patients. Here we evaluate the presence of genes encoding Panton-Valentine leukocidin (PVL), enterotoxins, TSST-1, exfoliative toxins, and the accessory gene regulatory locus by polymerase chain reaction (PCR) in S. aureus isolates obtained from healthy and diseased skin regions and anterior nares of psoriasis patients and healthy controls. Materials and methods: The presence of PVL and toxin genes was investigated, and agr typing was performed by PCR. Results: Eighteen of the isolated strains carried the sei, 1 carried the seb-sec, and 1 carried the seg enterotoxin gene. Eight of the strains carrying enterotoxin genes were isolated from nasal swabs, 6 from diseased skin swabs, and 4 from healthy skin swabs. None of the strains isolated from the control group carried the agr locus. On the other hand, 11 of the S. aureus strains isolated from the patients carried type 1, 7 carried type 1 + 3, 4 carried type 2, 4 carried type 3, and 1 carried type 1 + 2 agr loci. Conclusion: Enterotoxin production and the carried accessory gene regulatory locus may be important in the aggravation of psoriasis.en_US
dc.identifier.citationGöçmen J. S., Şahiner N., Koçak M., Karahan Z. C. (2015). PCR investigation of Panton-Valentine leukocidin, enterotoxin, exfoliative toxin, and agr genes in Staphylococcus aureus strains isolated from psoriasis patients. Turkish Journal of Medical Sciences, 45(6), 1345 - 1352.en_US
dc.identifier.doi10.3906/sag-1408-54
dc.identifier.endpage1352en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid26775393
dc.identifier.scopus2-s2.0-84947437658
dc.identifier.scopusqualityQ1
dc.identifier.startpage1345en_US
dc.identifier.trdizinid186568
dc.identifier.urihttps://doi.org/10.3906/sag-1408-54
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6280
dc.identifier.volume45en_US
dc.identifier.wosWOS:000365510300025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolymerase chain reactionen_US
dc.subjectStaphylococcus aureusen_US
dc.subjecttoxin genesen_US
dc.subjectagr typingen_US
dc.titlePCR investigation of Panton-Valentine leukocidin, enterotoxin, exfoliative toxin, and agr genes in Staphylococcus aureus strains isolated from psoriasis patientsen_US
dc.typeArticle

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