Efficacy of topotecan treatment on antioxidant enzymes and TBA-RS levels in submandibular glands of rabbits: An experimental study

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dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorKısa, Üçler
dc.contributor.authorKaçmaz, Murat
dc.contributor.authorApan, Alparslan
dc.contributor.authorKoç, Can
dc.date.accessioned2020-06-25T17:40:53Z
dc.date.available2020-06-25T17:40:53Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810
dc.description.abstractOBJECTIVE: The aim of this study was to investigate the effects of topotecan (Hycamtin), a topoisomerase I inhibiting anticancer agent, on antioxidant enzymes (SOD, CAT, and GSH-Px) and TBA-RS values of the submandibular glands of the rabbits. STUDY DESIGN AND SETTING: The study was conveyed in two groups (Group I, II) and control with a total of 24 rabbits. Eight rabbits in group I received intravenous (i.v.) topotecan (0.25 mg/kg once daily) for 3 days. Eight rabbits in group II received i.v. topotecan (0.5 mg/kg once daily) for 3 days. On the 15th day after administration of topotecan, submandibular glands were removed and levels of the SOD, CAT, and GSH-Px and the TBA-RS in the submandibular glands of the rabbits were examined. RESULTS: SOD, CAT, and GSH-Px values were significantly higher in high-dose topotecan group compared to control group (P < 0.05). SOD and TBA-RS values were significantly higher in high-dose topotecan group compared to low-dose topotecan group (P < 0.05). CONCLUSION: It was concluded that, to prevent the hazardous effects of oxygen free radicals due to topotecan, antioxidant enzymes SOD, CAT, and GSH-Px were increased. The higher levels of the TBA-RS values in group II showed that permanent damage was present because of high-dose topotecan administration in the submandibular glands of the rabbits.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.otohns.2004.09.012
dc.identifier.endpage140en_US
dc.identifier.issn0194-5998
dc.identifier.issn1097-6817
dc.identifier.issue1en_US
dc.identifier.pmid15632925
dc.identifier.scopus2-s2.0-11144223271
dc.identifier.scopusqualityQ1
dc.identifier.startpage136en_US
dc.identifier.urihttps://doi.org/10.1016/j.otohns.2004.09.012
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3577
dc.identifier.volume132en_US
dc.identifier.wosWOS:000226216300025
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltden_US
dc.relation.ispartofOtolaryngology-Head And Neck Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEfficacy of topotecan treatment on antioxidant enzymes and TBA-RS levels in submandibular glands of rabbits: An experimental studyen_US
dc.typeArticle

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