Common viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter study from Türkiye

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dc.authoridKaçar, Dilek/0000-0003-0825-8316
dc.authoridÖzdemir, Zeynep Canan/0000-0002-9172-9627
dc.authoridOrhan, Mehmet Fatih/0000-0001-8081-6760
dc.contributor.authorKacar, Dilek
dc.contributor.authorKebudi, Rejin
dc.contributor.authorÖzyörük, Derya
dc.contributor.authorTuğcu, Deniz
dc.contributor.authorBahadir, Aysenur
dc.contributor.authorÖzdemir, Zeynep Canan
dc.contributor.authorÖzgüven, Ali Aykan
dc.date.accessioned2025-01-21T16:34:03Z
dc.date.available2025-01-21T16:34:03Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground. Microbiologic confirmation of respiratory tract infections gained importance during the coronavirus disease 2019 (COVID-19) pandemic. This study retrospectively evaluated seasonal distribution, clinical presentation, and complications of respiratory viral infections (RVIs) other than COVID-19 in children with cancer during and after the pandemic lockdown. Methods. Two hundred and sixty-five inpatient and outpatient RVI episodes in 219 pediatric cancer patients confirmed by multiplex reverse transcriptase polymerase chain reaction (RT-PCR) panels from 13 centers were enrolled. Results. Eighty-six (32.5%) of the total 265 episodes occurred in 16 months corresponding to the lockdowns in T & uuml;rkiye, and the remaining 67.5% in 10 months thereafter. Human rhinovirus/enterovirus (hRE) (48.3%) was the most common agent detected during and after lockdown. Parainfluenza virus (PIV) (23.0%), influenza virus (9.8%), and respiratory syncytial virus (RSV) (9.1%) were the other common agents. The 28.7% of episodes were lower respiratory tract infections (LRTIs), and complications and mortality were higher than upper respiratory tract infections (URTIs) (25.0% vs 5.3%). Bacteremia was identified in 11.5% of culture-drawn episodes. Treatment delay in one-third and death within four weeks after RVI in 4.9% of episodes were observed. Conclusion. During the pandemic, fewer episodes of RVIs occurred during the lockdown period. Respiratory viruses may cause complications, delays in treatment, and even death in children with cancer. Therefore, increased awareness of RVIs and rapid detection of respiratory viruses will benefit the prevention and, in some cases, abrupt supportive and some antiviral treatment of RVI in children with cancer.
dc.identifier.doi10.24953/turkjpediatr.2024.4536
dc.identifier.endpage411
dc.identifier.issn0041-4301
dc.identifier.issue4
dc.identifier.pmid39387429
dc.identifier.scopus2-s2.0-85206279620
dc.identifier.scopusqualityQ3
dc.identifier.startpage401
dc.identifier.trdizinid1268814
dc.identifier.urihttps://doi.org/10.24953/turkjpediatr.2024.4536
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1268814
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23900
dc.identifier.volume66
dc.identifier.wosWOS:001335682800002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish J Pediatrics
dc.relation.ispartofTurkish Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectrespiratory viral infections; children; cancer; COVID-19
dc.titleCommon viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter study from Türkiye
dc.typeArticle

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