The inhibition effect of garlic-derived compounds on human immunodeficiency virus type 1 and saquinavir
Yükleniyor...
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Garlic has been used as a traditional medicine to treat various diseases. Garlic reduces the risk of some diseases. This protective effect is due to the organosulfur compounds of garlic. The aim of this study was to investigate the inhibition effects of garlic-derived compounds on human immunodeficiency virus type 1 (HIV-1) and as the most important anti-HIV-1 medicine. The activation of saquinavir is believed to be the principal mechanism behind the protective effects of HIV-1. Our theoretical calculations are performed for blood phase by using the density functional theory for the main compounds of garlic. The chemical activity and solubility of ajoene and the mainly derived compounds of garlic as theoretical calculations are important for the medical research comparing with the other compounds of the garlic. The theoretical calculations have helped us to determine which active ingredient of the garlic having inhibition effects on HIV-1 and saquinavir.
Açıklama
gokalp, faik/0000-0003-4363-3839
Anahtar Kelimeler
density functional theory (DFT), docking, garlic compounds, human immunodeficiency virus type 1 (HIV-1), saquinavir
Kaynak
Journal Of Biochemical And Molecular Toxicology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
32
Sayı
11
Künye
closedAccess
