The inhibition effect of garlic-derived compounds on human immunodeficiency virus type 1 and saquinavir

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dc.contributor.authorGokalp, Faik
dc.date.accessioned2020-06-25T18:29:21Z
dc.date.available2020-06-25T18:29:21Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptiongokalp, faik/0000-0003-4363-3839
dc.description.abstractGarlic has been used as a traditional medicine to treat various diseases. Garlic reduces the risk of some diseases. This protective effect is due to the organosulfur compounds of garlic. The aim of this study was to investigate the inhibition effects of garlic-derived compounds on human immunodeficiency virus type 1 (HIV-1) and as the most important anti-HIV-1 medicine. The activation of saquinavir is believed to be the principal mechanism behind the protective effects of HIV-1. Our theoretical calculations are performed for blood phase by using the density functional theory for the main compounds of garlic. The chemical activity and solubility of ajoene and the mainly derived compounds of garlic as theoretical calculations are important for the medical research comparing with the other compounds of the garlic. The theoretical calculations have helped us to determine which active ingredient of the garlic having inhibition effects on HIV-1 and saquinavir.en_US
dc.description.sponsorshipScientific Research Projects of Kirikkale University [BAP-2017/019-2018/033]en_US
dc.description.sponsorshipScientific Research Projects of Kirikkale University, Grant/Award Number: BAP-2017/019-2018/033en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/jbt.22215
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue11en_US
dc.identifier.pmid30194790
dc.identifier.scopus2-s2.0-85052966458
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.22215
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7265
dc.identifier.volume32en_US
dc.identifier.wosWOS:000449993000010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biochemical And Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdensity functional theory (DFT)en_US
dc.subjectdockingen_US
dc.subjectgarlic compoundsen_US
dc.subjecthuman immunodeficiency virus type 1 (HIV-1)en_US
dc.subjectsaquinaviren_US
dc.titleThe inhibition effect of garlic-derived compounds on human immunodeficiency virus type 1 and saquinaviren_US
dc.typeArticle

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