A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase

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dc.authoridLotti, Torello/0000-0003-0840-1936
dc.authoridİlanbey, Bilal/0000-0002-7614-281X
dc.authoridSözmen, Eser Yıldırım/0000-0002-6383-6724
dc.contributor.authorİlanbey, Bilal
dc.contributor.authorElmas, Ömer Faruk
dc.contributor.authorSözmen, Eser Yıldırım
dc.contributor.authorGünay, Umran
dc.contributor.authorDemirbaş, Abdullah
dc.contributor.authorAtasoy, Mustafa
dc.contributor.authorTursen, Ümit
dc.date.accessioned2025-01-21T16:34:25Z
dc.date.available2025-01-21T16:34:25Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: Chitotriosidase (ChT) is an enzyme secreted by activated macrophages and neutrophils in response to proinflammatory signals. There is growing evidence indicating that ChT activity reflects the systemic inflammatory status. This study aimed to investigate whether serum ChT activity increased in patients with psoriasis and related comorbidities. Materials and methods: This cross-sectional study included 53 (28 with associated comorbidities and 25 without comorbidities) patients with psoriasis and 52 healthy volunteers. All participants underwent laboratory investigations for serum ChT levels, complete blood count, erythrocyte sedimentation rate, C-reactive protein, and serum lipid levels. Results: The patients with psoriasis showed significantly higher levels of ChT activity as compared to the healthy controls (23.5 +/- 11.4 vs. 17.5 +/- 10.4 mu mol/mL/hour; p = 0.015). Additionally, the ChT activity was significantly higher in patients with comorbidities than in those without (p = 0.042). Conclusion: Our data support the pathogenetic role of inflammatory processes induced by macrophage activation in patients with psoriasis and related comorbidities. We believe that high ChT activity in patients with psoriasis may serve as an early prediction of the possible related comorbidities.
dc.identifier.doi10.3906/sag-2101-137
dc.identifier.endpage2323
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5
dc.identifier.pmid33819975
dc.identifier.scopus2-s2.0-85120666254
dc.identifier.scopusqualityQ1
dc.identifier.startpage2318
dc.identifier.trdizinid478912
dc.identifier.urihttps://doi.org/10.3906/sag-2101-137
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay478912
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23965
dc.identifier.volume51
dc.identifier.wosWOS:000711339600011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectChitotriosidase; comorbidity; macrophage; psoriasis
dc.titleA novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase
dc.typeArticle

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